SREBP1 Antibody
Novus Biologicals, part of Bio-Techne | Catalog # NBP2-54707
Key Product Details
Species Reactivity
Human
Applications
Immunohistochemistry, Immunohistochemistry-Paraffin
Label
Unconjugated
Antibody Source
Polyclonal Rabbit IgG
Concentration
Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.
Product Specifications
Immunogen
This antibody was developed against a Recombinant Protein corresponding to amino acids: SLLLTAMKTDGATVKAAGLSPLVSGTTVQTGPLPTLVSGGTILATVPLVVDAEKLPINRLAAGSKAPASAQSRGEKRTAHNAI
Reactivity Notes
Immunogen displays the following percentage of sequence identity for non-tested species: Mouse (82%),
Clonality
Polyclonal
Host
Rabbit
Isotype
IgG
Scientific Data Images for SREBP1 Antibody
![Immunohistochemistry-Paraffin: SREBP1 Antibody [NBP2-54707]](https://resources.bio-techne.com/images/products/SREBP1-Antibody-Immunohistochemistry-Paraffin-NBP2-54707-img0001.jpg "Immunohistochemistry-Paraffin: SREBP1 Antibody [NBP2-54707]")
Immunohistochemistry-Paraffin: SREBP1 Antibody [NBP2-54707]
Immunohistochemistry-Paraffin: SREBP1 Antibody [NBP2-54707] - Staining of human adrenal gland shows strong cytoplasmic positivity in glandular cells.Applications for SREBP1 Antibody
Application
Recommended Usage
Immunohistochemistry
1:200 - 1:500
Immunohistochemistry-Paraffin
1:200 - 1:500
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.
Formulation, Preparation, and Storage
Purification
Immunogen affinity purified
Formulation
PBS (pH 7.2) and 40% Glycerol
Preservative
0.02% Sodium Azide
Concentration
Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.
Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Background: SREBP1
SREBP1 is a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription. The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family. This gene is located within the Smith-Magenis syndrome region on chromosome 17.
Long Name
Sterol regulatory element-binding protein 1
Alternate Names
bHLHd1, SREBF1, SREBP-1
Gene Symbol
SREBF1
Additional SREBP1 Products
Product Documents for SREBP1 Antibody
Product Specific Notices for SREBP1 Antibody
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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