SUCNR1/GPR91 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-27860

Novus Biologicals, part of Bio-Techne
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NBP3-27860-100ul
NBP3-27860-50ul
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Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat, Porcine

Applications

ELISA, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all SUCNR1/GPR91 Antibodies »

Product Summary for SUCNR1/GPR91 Antibody

Immunogen

The antiserum was produced against synthesized peptide derived from human SUCNR1/GPR91. (Uniprot #: Q9BXA5)

Specificity

Detects endogenous levels of SUCNR1/GPR91

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

38 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for SUCNR1/GPR91 Antibody

SUCNR1/GPR91 Antibody

Western Blot: SUCNR1/GPR91 Antibody [NBP3-27860] -

Western Blot: SUCNR1/GPR91 Antibody [NBP3-27860] - Western blot analysis of lysates from HUVEC and MCF-7 cells, using NBP3-27860. The lane on the right is blocked with the synthesized peptide.

Applications for SUCNR1/GPR91 Antibody

Application
Recommended Usage

ELISA

1:10000

Western Blot

1:500 - 1:2000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Antigen Affinity-purified

Formulation

PBS, 50% glycerol, 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: SUCNR1/GPR91

GPR91 (formerly known as P2U2) is a G protein-coupled, dicarboxylic acid succinate receptor. It has a high level of expression in the kidney, predominantly in the proximal tubules, and localizes to the plasma membrane. It has also been found at low levels in the liver and the spleen. GPR91 functions as a citric acid cycle intermediate succinate receptor. Two signaling pathways result from GPR91 activation, the pertussis-toxin-sensitive Gi/Go pathway and the pertussis-toxin-insensitive Gq pathway. Four amino acid residues are necessary for GPR91 activation by succinate: Arg 99, His 103, Arg 252 and Arg 281. GPR91 plays an important role in the succinate-induced hypertensive effect and may be involved in renovascular hypertension, a disease linked to diabetes, renal failure and atherosclerosis.

Long Name

Succinate Receptor 1

Alternate Names

GPR91

Gene Symbol

SUCNR1

Additional SUCNR1/GPR91 Products

Product Documents for SUCNR1/GPR91 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for SUCNR1/GPR91 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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