SUR1 is encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a modulator of ATP-sensitive potassium channels and insulin release. Mutations and deficiencies in this protein have been observed in patients with hyperinsulinemic hypoglycemia of infancy, an autosomal recessive disorder of unregulated and high insulin secretion. Mutations have also been associated with non-insulin-dependent diabetes mellitus type II, an autosomal dominant disease of defective insulin secretion. Alternative splicing of this gene has been observed; however, the transcript variants have not been fully described.

Long Name

ATP-binding cassette sub-family C member 8

Alternate Names

ABCC8, HRINS, SUR

Gene Symbol

ABCC8

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Product Documents for SUR1 Antibody (S289-16) [Biotin]

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Product Specific Notices for SUR1 Antibody (S289-16) [Biotin]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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SUR1 Antibody (S289-16) [Biotin]

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-59320B

Key Product Details

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Applications for SUR1 Antibody (S289-16) [Biotin]

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Background: SUR1