SUR1 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-34077

Novus Biologicals, part of Bio-Techne
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NBP2-34077
NBP2-34077-25ul
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Key Product Details

Species Reactivity

Validated:

Human, Mouse

Cited:

Mouse

Predicted:

Rat (96%). Backed by our 100% Guarantee.

Applications

Validated:

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Knockdown Validated

Cited:

Immunocytochemistry/ Immunofluorescence, Knockdown Validated

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all SUR1 Antibodies »

Product Specifications

Immunogen

This antibody was developed against a recombinant protein corresponding to amino acids: DHLGKENDVFQPKTQFLGVYFVSSQ

Reactivity Notes

Mouse reactivity reported in scientific literature (PMID: 31067750).

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for SUR1 Antibody

Immunocytochemistry/ Immunofluorescence: SUR1 Antibody [NBP2-34077]

Immunocytochemistry/ Immunofluorescence: SUR1 Antibody [NBP2-34077]

Immunocytochemistry/Immunofluorescence: SUR1 Antibody [NBP2-34077] - Staining of human cell line U-2 OS shows localization to nucleoli, cytosol & the Golgi apparatus. Antibody staining is shown in green.
Immunohistochemistry-Paraffin: SUR1 Antibody [NBP2-34077]

Immunohistochemistry-Paraffin: SUR1 Antibody [NBP2-34077]

Immunohistochemistry-Paraffin: SUR1 Antibody [NBP2-34077] - Staining of human cerebellum shows strong cytoplasmic positivity in purkinje cells.
Immunohistochemistry: SUR1 Antibody [NBP2-34077]

Immunohistochemistry: SUR1 Antibody [NBP2-34077]

Immunohistochemistry: SUR1 Antibody [NBP2-34077] - IHC using NBP2-34077 at a dilution of 1:50 on FFPE human placenta. Primary antibody was incubated overnight at 4 C, then secondary HRP conjugate applied for 1 hour RT and visualized with DAB. HIER performed with citrate buffer pH 6.0 at 95 C for 15 minutes. Antibody incubation with 10x immunogenic peptide shows no staining. Image submitted by a verified customer review.
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Applications for SUR1 Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

0.25-2 ug/ml

Immunohistochemistry

1:50 - 1:200

Immunohistochemistry-Paraffin

1:50 - 1:200
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended. ICC/IF Fixation Permeabilization: Use PFA/Triton X-100. Use in Knockdown Validated reported in scientific literature (PMID: 31067750). SUR1 antibody validated for IHC from a verified customer review.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Reviewed Applications

Read 1 review rated 4 using NBP2-34077 in the following applications:

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: SUR1

SUR1 is encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a modulator of ATP-sensitive potassium channels and insulin release. Mutations and deficiencies in this protein have been observed in patients with hyperinsulinemic hypoglycemia of infancy, an autosomal recessive disorder of unregulated and high insulin secretion. Mutations have also been associated with non-insulin-dependent diabetes mellitus type II, an autosomal dominant disease of defective insulin secretion. Alternative splicing of this gene has been observed; however, the transcript variants have not been fully described.

Long Name

ATP-binding cassette sub-family C member 8

Alternate Names

ABCC8, HRINS, SUR

Gene Symbol

ABCC8

UniProt

Q09428 (Human)

Additional SUR1 Products

Product Documents for SUR1 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for SUR1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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