Syntaxin-BP1 [p Ser241] Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-29507

Novus Biologicals, part of Bio-Techne
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Key Product Details

Validated by

Biological Validation

Species Reactivity

Validated:

Mouse, Rat

Predicted:

Bovine (100%), Canine (100%), Chicken (100%), Human (100%), Primate (100%), Rat (100%), Sheep (100%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all Syntaxin-BP1 Antibodies »

Product Specifications

Immunogen

Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser241 conjugated to KLH. Accession # O08599

Modification

p Ser241

Specificity

Specific for endogenous levels of the ~65 kDa Syntaxin-BP1 protein phosphorylated at Ser241. Immunolabeling is completely eliminated by treatment with lambda-phosphatase.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

65 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for Syntaxin-BP1 [p Ser241] Antibody

Western Blot: Syntaxin-BP1 [p Ser241] Antibody [NBP2-29507]

Western Blot: Syntaxin-BP1 [p Ser241] Antibody [NBP2-29507]

Western Blot: STXBP1 [p Ser241] Antibody [NBP2-29507] - Western blot of mouse hippocampus lysate showing specific immunolabeling of the ~65k Munc18-1 protein phosphorylated at Ser241. Phosphospecificity is shown in the second lane where immunolabeling is blocked by treatment of the lysate with lambda phosphatase (P-tase).

Applications for Syntaxin-BP1 [p Ser241] Antibody

Application
Recommended Usage

Immunohistochemistry

1:500

Western Blot

1:1000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Antigen Affinity-purified

Formulation

10mM HEPES (pH 7.5), 0.15M NaCl, 0.1 mg/ml BSA and 50% Glycerol

Preservative

No Preservative

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: Syntaxin-BP1

Munc-18 (mammalian homologue of Unc-18) is a protein that is thought to be involved in regulating exocytosis due, at least in part, to it ability to bind syntaxin (Ciufo et al., 2005). Munc18-1 is a neuron-specific member of the Sec1/Munc18 protein family that binds to syntaxin1A and is thought to stabilize the complex (Liu et al., 2004). The function of Munc18-1 is thought to be regulated by phosphorylation.

Long Name

Syntaxin-binding Protein 1

Alternate Names

EIEE4, p67, rbSec1, STXBP1, SyntaxinBP1, UNC18

Entrez Gene IDs

20910 (Mouse)

Gene Symbol

STXBP1

UniProt

O08599 (Mouse)

Additional Syntaxin-BP1 Products

Product Documents for Syntaxin-BP1 [p Ser241] Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Syntaxin-BP1 [p Ser241] Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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