Tankyrase 1 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-80947

Novus Biologicals, part of Bio-Techne
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NBP1-80947
NBP1-80947-25ul
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Key Product Details

Species Reactivity

Validated:

Human

Applications

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Tankyrase 1 Antibodies »

Product Summary for Tankyrase 1 Antibody

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: SPDPVDGTSCCSTTSTICTVAAAPVVPAVSTSSAAGVAPNPAGSGSNNSPSSSSSPTSSSSSSPSS

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Tankyrase 1 Antibody

Immunocytochemistry/ Immunofluorescence: Tankyrase 1 Antibody [NBP1-80947]

Immunocytochemistry/ Immunofluorescence: Tankyrase 1 Antibody [NBP1-80947]

Immunocytochemistry/Immunofluorescence: Tankyrase 1 Antibody [NBP1-80947] - Staining of human cell line A-431 shows localization to nucleoplasm & nuclear membrane. Antibody staining is shown in green.
Immunohistochemistry-Paraffin: Tankyrase 1 Antibody [NBP1-80947]

Immunohistochemistry-Paraffin: Tankyrase 1 Antibody [NBP1-80947]

Immunohistochemistry-Paraffin: Tankyrase 1 Antibody [NBP1-80947] - Staining of human liver shows moderate cytoplasmic positivity in hepatocytes.

Applications for Tankyrase 1 Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

0.25-2 ug/ml

Immunohistochemistry

1:20 - 1:50

Immunohistochemistry-Paraffin

1:20 - 1:50
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended. Immunocytochemistry/Immunofluorescence Fixation Permeabilization: Use PFA/Triton X-100.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Tankyrase 1

The ~142 kDa Tankyrase protein is ubiquitously expressed in mammalian cells and is localized to human telomeres. It has homology to ankyrins and to the catalytic domain of poly (adenosine diphosphate-ribose) polymerase (PARP). Tankyrase binds to TRF1 (telomeric repeat binding factor-1), which negatively regulates the maintenance of telomere length.

Long Name

TRF1-interacting Ankyrin-related ADP-ribose Polymerase

Alternate Names

PARP5A, PARPL, pART5, TANK1, TINF1, TNKS

Entrez Gene IDs

8658 (Human)

Gene Symbol

TNKS

UniProt

O95271 (Human)

Additional Tankyrase 1 Products

Product Documents for Tankyrase 1 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Tankyrase 1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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