Tbp7 Antibody (3G8)

Novus Biologicals, part of Bio-Techne | Catalog # H00005704-M01

Novus Biologicals, part of Bio-Techne
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Key Product Details

Species Reactivity

Human

Applications

ELISA, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Sandwich ELISA, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG2a Kappa Clone # 3G8

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Tbp7 Antibodies »

Product Specifications

Immunogen

PSMC4 (AAH00343, 1 a.a. ~ 418 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. MEEIGILVEKAQDEIPALSVSRPQTGLSFLGPEPEDLEDLYSRYKKLQQELEFLEVQEEYIKDEQKNLKKEFLHAQEEVKRIQSIPLVIGQFLEAVDQNTAIVGSTTGSNYYVRILSTIDRELLKPNASVALHKHSNALVDVLPPEADSSIMMLTSDQKPDVMYADIGGMDIQKQEVREAVELPLTHFELYKQIGIDPPRGVLMYGPPGCGKTMLAKAVAHHTTAAFIRVVGSEFVQKYLGEGPRMVRDVFRLAKENAPAIIFIDEIDAIATKRFDAQTGADREVQRILLELLNQMDGFDQNVNVKVIMATNRADTLDPALLRPGRLDRKIEFPLPDRRQKRLIFSTITSKMNLSEEVDLEDYVARPDKISGADINSICQESGMLAVRENRYIVLAKDFEKAYKTVIKKDEQEHEFYK

Specificity

PSMC4 - proteasome (prosome, macropain) 26S subunit, ATPase, 4

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2a Kappa

Description

Quality control test: Antibody Reactive Against Recombinant Protein.

Scientific Data Images for Tbp7 Antibody (3G8)

Western Blot: Tbp7 Antibody (3G8) [H00005704-M01]

Western Blot: Tbp7 Antibody (3G8) [H00005704-M01]

Western Blot: Tbp7 Antibody (3G8) [H00005704-M01] - Analysis of PSMC4 expression in transfected 293T cell line by PSMC4 monoclonal antibody (M01), clone 3G8.Lane 1: PSMC4 transfected lysate(47.4 KDa).Lane 2: Non-transfected lysate.
Immunocytochemistry/ Immunofluorescence: Tbp7 Antibody (3G8) [H00005704-M01]

Immunocytochemistry/ Immunofluorescence: Tbp7 Antibody (3G8) [H00005704-M01]

Immunocytochemistry/Immunofluorescence: Tbp7 Antibody (3G8) [H00005704-M01] - Analysis of monoclonal antibody to PSMC4 on HepG2 cell. Antibody concentration 10 ug/ml.
Immunohistochemistry-Paraffin: Tbp7 Antibody (3G8) [H00005704-M01]

Immunohistochemistry-Paraffin: Tbp7 Antibody (3G8) [H00005704-M01]

Immunohistochemistry-Paraffin: Tbp7 Antibody (3G8) [H00005704-M01] - Analysis of monoclonal antibody to PSMC4 on formalin-fixed paraffin-embedded human colon. Antibody concentration 3 ug/ml.
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Applications for Tbp7 Antibody (3G8)

Application
Recommended Usage

Western Blot

1:500
Application Notes
Antibody reactivity against cell lysate and recombinant protein for WB. It has also been used for IF, IHC-P and ELISA.

Formulation, Preparation, and Storage

Purification

IgG purified

Formulation

In 1x PBS, pH 7.4

Preservative

No Preservative

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Background: Tbp7

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit has been shown to interact with an orphan member of the nuclear hormone receptor superfamily highly expressed in liver, and with gankyrin, a liver oncoprotein. Two transcript variants encoding different isoforms have been identified.

Alternate Names

MB67 interacting protein, MGC13687,26S protease regulatory subunit 6B, MGC23214, MGC8570, protease 26S subunit 6, proteasome (prosome, macropain) 26S subunit, ATPase, 4,26S proteasome AAA-ATPase subunit RPT3, Proteasome 26S subunit ATPase 4, S6Tat-binding protein 7, TBP-7MB67-interacting protein, TBP7MIP224

Entrez Gene IDs

5704 (Human)

Gene Symbol

PSMC4

OMIM

602707 (Human)

UniProt

AAH00343 (Human)

Additional Tbp7 Products

Product Documents for Tbp7 Antibody (3G8)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Tbp7 Antibody (3G8)

This product is produced by and distributed for Abnova, a company based in Taiwan.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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