TDP1 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB100-81642

Novus Biologicals, part of Bio-Techne
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NB100-81642
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Key Product Details

Validated by

Independent Antibodies, Biological Validation

Species Reactivity

Validated:

Human

Cited:

Human

Applications

Validated:

Immunohistochemistry, Immunohistochemistry-Paraffin, Immunoprecipitation, Western Blot

Cited:

Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

0.2 mg/ml

View all TDP1 Antibodies »

Product Specifications

Immunogen

The immunogen recognized by this antibody maps to a region between residue 1 and 50 of human tyrosyl-DNA phosphodiesterase 1 (NP_001008744.1).

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for TDP1 Antibody

Western Blot: TDP1 Antibody [NB100-81642]

Western Blot: TDP1 Antibody [NB100-81642]

Western Blot: TDP1 Antibody [NB100-81642] - Detection of Human TDP1 on HeLa whole cell lysate using NB100-81642. TDP1 was also immunoprecipitated by rabbit anti-TDP1 antibody NB100-81643.
Immunohistochemistry-Paraffin: TDP1 Antibody [NB100-81642]

Immunohistochemistry-Paraffin: TDP1 Antibody [NB100-81642]

Immunohistochemistry-Paraffin: TDP1 Antibody [NB100-81642] - Sample: FFPE section of human ovarian carcinoma. Antibody: Affinity purified rabbit anti- TDP1 used at a dilution of 1:1,000 (0.2ug/ml). Detection: DAB

Applications for TDP1 Antibody

Application
Recommended Usage

Immunohistochemistry

1:1000-1:500

Immunohistochemistry-Paraffin

1:1000-1:500

Immunoprecipitation

2-5 ug/mg lysate

Western Blot

1:2000-1:10000
Application Notes
Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

TBS and 0.1% BSA

Preservative

0.09% Sodium Azide

Concentration

0.2 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C. Do not freeze.

Background: TDP1

The protein encoded by this gene is involved in repairing stalled topoisomerase I-DNA complexes by catalyzing the hydrolysis of the phosphodiester bond between the tyrosine residue of topoisomerase I and the 3-prime phosphate of DNA. This protein may also remove glycolate from single-stranded DNA containing 3-prime phosphoglycolate, suggesting a role in repair of free-radical mediated DNA double-strand breaks. This gene is a member of the phospholipase D family and contains two PLD phosphodiesterase domains. Mutations in this gene are associated with the disease spinocerebellar ataxia with axonal neuropathy (SCAN1). While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same isoform.

Alternate Names

EC 3.1.4, EC 3.1.4.-, FLJ11090, MGC104252, SCAN1, Tyr-DNA phosphodiesterase 1, tyrosyl-DNA phosphodiesterase 1

Entrez Gene IDs

55775 (Human)

Gene Symbol

TDP1

UniProt

Q9NUW8 (Human)

Additional TDP1 Products

Product Documents for TDP1 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for TDP1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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