Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

ELISA, Immunocytochemistry/ Immunofluorescence, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

1 mg/ml

View all TEM8/ANTXR1 Antibodies »

Product Specifications

Immunogen

Antibody was raised against a peptide corresponding to 13 amino acids near the C-terminus of human TEM8/ANTXR1. The immunogen is located within the last 50 amino acids.. Amino Acid Squence: RAPPPSRPPPRPSV

Specificity

TEM8/ANTXR1 antibody will recognize only the largest isoform.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for TEM8/ANTXR1 Antibody - BSA Free

TEM8/ANTXR1 Antibody - BSA Free

Western Blot-NBP3-21501-TEM8/ANTXR1 Antibody - BSA Free-

Western Blot-NBP3-21501-TEM8/ANTXR1 Antibody - BSA Free-analysis of ATR in K562 cell lysates with ATR antibody at (A) 0.5, (B) 1, and (C) 2 ug/mL.
TEM8/ANTXR1 Antibody - BSA Free

ICC/IF-NBP3-21501-TEM8/ANTXR1 Antibody - BSA Free-

ICC/IF-NBP3-21501-TEM8/ANTXR1 Antibody - BSA Free-ATR in K562 cells with ATR antibody at 2 ug/mL.
TEM8/ANTXR1 Antibody - BSA Free

ICC/IF-NBP3-21501-TEM8/ANTXR1 Antibody - BSA Free-

ICC/IF-NBP3-21501-TEM8/ANTXR1 Antibody - BSA Free-ATR in K562 cells with ATR antibody at 10 ug/mL.

Applications for TEM8/ANTXR1 Antibody - BSA Free

Application
Recommended Usage

ELISA

1:100-1:2000

Immunocytochemistry/ Immunofluorescence

2-10 ug/ml

Western Blot

0.5-2 ug/ml

Formulation, Preparation, and Storage

Purification

Ion exchange chromatography

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: TEM8/ANTXR1

The Anthrax toxin receptor (ATR) was initially discovered as the tumor endothelial marker 8 (TEM8). This protein, which exists in three isoforms (36, 40, and 60 kDa), is highly expressed in tumor vessels as well as in the vasculature of developing embryos, suggesting that it may normally play a role in angiogenesis. However, it also acts as the receptor for anthrax toxin. Following the binding of this protein by the protective antigen (PA) of anthrax, PA is cleaved and heptamerizes to form the binding site for both edema factor (EF) and lethal factor (LF). This complex is then endocytosed by the cell; acidification in endosomes allows the release of EF and LF into the cytoplasm where they interfere with MAPK signaling and induce apoptosis.

Long Name

Tumor Endothelial Marker 8/Anthrax Toxin Receptor 1

Alternate Names

ANTXR1

Gene Symbol

ANTXR1

UniProt

NP_444262 (Human)

Additional TEM8/ANTXR1 Products

Product Documents for TEM8/ANTXR1 Antibody - BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for TEM8/ANTXR1 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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