Thioredoxin Reductase 1/TRXR1 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB300-879

Novus Biologicals, part of Bio-Techne
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NB300-879
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Porcine (100%). Backed by our 100% Guarantee.

Applications

Peptide ELISA, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG

Concentration

0.5 mg/ml

View all Thioredoxin Reductase 1/TRXR1 Antibodies »

Product Specifications

Immunogen

Peptide with sequence TKRSGASILQAGC corresponding to C-Terminus according to NP_003321.2, NP_877393.1, NP_877419.1, NP_877420.1, NP_001087240.1.

Specificity

This antibody is expected to recognise reported isoform 1 (NP_003321.2), isoform 2 (NP_877393.1; NP_877419.1; NP_877420.1) and isoform 3 (NP_001087240.1)

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for Thioredoxin Reductase 1/TRXR1 Antibody

Western Blot: Thioredoxin Reductase 1/TRXR1 Antibody [NB300-879]

Western Blot: Thioredoxin Reductase 1/TRXR1 Antibody [NB300-879]

Western Blot: thioredoxin reductase 1 Antibody [NB300-879] - (0.1ug/ml) of Human Placenta lysate (RIPA buffer, 35ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.

Applications for Thioredoxin Reductase 1/TRXR1 Antibody

Application
Recommended Usage

Peptide ELISA

Detection limit 1:32000

Western Blot

0.1 - 1 ug/ml
Application Notes
WB: Approx. 60 kDa band observed in human placenta lysates (predicted MW of 57 kDa band according to NP_003321).

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: Thioredoxin Reductase 1/TRXR1

This protein is a pyridine nucleotide oxidoreductase which reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress. It is thought to function as a homodimer which uses FAD as a cofactor. Each subunit contains a selenocysteine residue which is required for the catalytic activity. Alternative splicing results in several transcript variants encoding the same protein. Additional transcript variants have been described but their biological validity has not been determined.

Alternate Names

GRIM-12, KDRF, TR1, TRXR1, TRXRD1, TXNR, TXNRD1

Entrez Gene IDs

7296 (Human)

Gene Symbol

TXNRD1

UniProt

NP_003321. (Human)

Additional Thioredoxin Reductase 1/TRXR1 Products

Product Documents for Thioredoxin Reductase 1/TRXR1 Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Thioredoxin Reductase 1/TRXR1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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