Thioredoxin Reductase 1/TRXR1 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-20620

Novus Biologicals, part of Bio-Techne
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NBP2-20620
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Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat

Predicted:

Bovine (92%), Canine (95%), Porcine (92%), Primate (98%), Rabbit (94%), Rhesus Macaque (98%). Backed by our 100% Guarantee.

Applications

Validated:

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Cited:

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Thioredoxin Reductase 1/TRXR1 Antibodies »

Product Specifications

Immunogen

Recombinant protein encompassing a sequence within the center region of human Thioredoxin Reductase 1/TRXR1. The exact sequence is proprietary.

Reactivity Notes

Chimpanzee (99%), Xenopus laevis (82%), Chicken (85%).

Localization

Cytoplasm; Isoform 4: Cytoplasm; Nucleus; Isoform 5: Cytoplasm

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

71 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for Thioredoxin Reductase 1/TRXR1 Antibody

Western Blot: Thioredoxin Reductase 1/TRXR1 Antibody [NBP2-20620]

Western Blot: Thioredoxin Reductase 1/TRXR1 Antibody [NBP2-20620]

Western Blot: thioredoxin reductase 1 Antibody [NBP2-20620] - Sample (30 ug of whole cell lysate) A: A549 B: H1299 C: HCT116 7. 5% SDS PAGE gel, diluted at 1:1000.
Immunocytochemistry/ Immunofluorescence: Thioredoxin Reductase 1/TRXR1 Antibody [NBP2-20620]

Immunocytochemistry/ Immunofluorescence: Thioredoxin Reductase 1/TRXR1 Antibody [NBP2-20620]

Immunocytochemistry/Immunofluorescence: Thioredoxin Reductase 1/TRXR1 Antibody [NBP2-20620] - HeLa cells were fixed in 4% paraformaldehyde at RT for 15 min. Green: TrxR1 protein stained by TrxR1 antibody diluted at 1:500. Blue: Hoechst 33342 staining. Scale bar = 10 um.
Immunohistochemistry-Paraffin: Thioredoxin Reductase 1/TRXR1 Antibody [NBP2-20620]

Immunohistochemistry-Paraffin: Thioredoxin Reductase 1/TRXR1 Antibody [NBP2-20620]

Immunohistochemistry-Paraffin: Thioredoxin Reductase 1/TRXR1 Antibody [NBP2-20620] - Analysis of paraffin-embedded RT2 xenograft, using antibody at 1:500 dilution.
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Applications for Thioredoxin Reductase 1/TRXR1 Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

1:100-1:1000

Immunohistochemistry

1:100-1:1000

Immunohistochemistry-Paraffin

1:100-1:1000

Western Blot

1:500-1:3000

Formulation, Preparation, and Storage

Purification

Antigen Affinity-purified

Formulation

PBS (pH 7), 20% Glycerol, 1% BSA

Preservative

0.01% Thimerosal

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Background: Thioredoxin Reductase 1/TRXR1

This gene encodes a member of the family of pyridine nucleotide oxidoreductases. This protein reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress. The functional enzyme is thought to be a homodimer which uses FAD as a cofactor. Each subunit contains a selenocysteine (Sec) residue which is required for catalytic activity. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenocysteine-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in several transcript variants encoding the same or different isoforms. [provided by RefSeq]

Alternate Names

GRIM-12, KDRF, TR1, TRXR1, TRXRD1, TXNR, TXNRD1

Gene Symbol

TXNRD1

UniProt

Q16881

Additional Thioredoxin Reductase 1/TRXR1 Products

Product Documents for Thioredoxin Reductase 1/TRXR1 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for Thioredoxin Reductase 1/TRXR1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause reproductive toxicity with developmental effects.  For more information go to www.P65Warnings.ca.gov.

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