Thyroid Peroxidase Antibody (TPO/1922) [Janelia Fluor® 646]
Novus Biologicals, part of Bio-Techne | Catalog # NBP2-79923JF646
Conjugate
Catalog #
Forumulation
Catalog #
Key Product Details
Species Reactivity
Validated:
Human
Applications
Immunohistochemistry, Immunohistochemistry-Paraffin, Protein Array
Label
Janelia Fluor 646
Antibody Source
Monoclonal Mouse IgG1 kappa Clone # TPO/1922
Concentration
Please see the vial label for concentration. If unlisted please contact technical services.
Product Summary for Thyroid Peroxidase Antibody (TPO/1922) [Janelia Fluor® 646]
Immunogen
Recombinant fragment of human Thyroid Peroxidase (around aa 685-804) (Exact sequence is proprietary) (Uniprot: P07202)
Localization
Cytoplasmic, Cell Surface
Specificity
Thyroperoxidase (TPO) is a 933-amino acid, type I transmembrane glycoprotein that plays a key role in thyroid gland function and autoimmunity. It is present as a dimer on the apical surface of thyroid follicular cells. TPO functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Malignant thyroid tumors exhibit an anomaly in TPO resulting in lower affinity for anti-TPO. This antibody may aid in the differentiation between benign and malignant thyroid tumors.
Marker
Thyroid Marker
Clonality
Monoclonal
Host
Mouse
Isotype
IgG1 kappa
Applications for Thyroid Peroxidase Antibody (TPO/1922) [Janelia Fluor® 646]
Application
Recommended Usage
Immunohistochemistry
Optimal dilutions of this antibody should be experimentally determined.
Immunohistochemistry-Paraffin
Optimal dilutions of this antibody should be experimentally determined.
Protein Array
Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Optimal dilution of this antibody should be experimentally determined.
Please Note: Optimal dilutions of this antibody should be experimentally determined.
Formulation, Preparation, and Storage
Purification
Protein A or G purified
Formulation
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Concentration
Please see the vial label for concentration. If unlisted please contact technical services.
Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store at 4C in the dark.
Background: Thyroid Peroxidase
Alternate Names
EC 1.11.1, MSA, TDH2A, thyroid microsomal antigen, thyroid peroxidase, thyroperoxidase, TPXEC 1.11.1.8
Gene Symbol
TPO
Additional Thyroid Peroxidase Products
Product Documents for Thyroid Peroxidase Antibody (TPO/1922) [Janelia Fluor® 646]
Product Specific Notices for Thyroid Peroxidase Antibody (TPO/1922) [Janelia Fluor® 646]
Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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