TIRAP Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB100-2823

Novus Biologicals, part of Bio-Techne
Catalog #
Availability
Size / Price
Qty
NB100-2823
Print Quote
Bulk Order
100% Guarantee

Key Product Details

Species Reactivity

Human

Applications

Peptide ELISA, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG

Concentration

0.5 mg/ml

View all TIRAP Antibodies »

Product Specifications

Immunogen

Peptide with sequence C-QTLLKKPKKRPNSPE corresponding to internal region according to NP_001034750.1, NP_683708.1.

Specificity

This antibody is expected to recognize both reported isoforms (NP_001034750.1 and NP_683708.1).

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for TIRAP Antibody

Western Blot: TIRAP Antibody [NB100-2823]

Western Blot: TIRAP Antibody [NB100-2823]

Western Blot: TIRAP Antibody [NB100-2823] - Staining (0.3µg/ml) of A549 (A) and K562 (B) cell lysate (35µg protein in RIPA buffer). Detected by chemiluminescence.
Western Blot: TIRAP Antibody [NB100-2823]

Western Blot: TIRAP Antibody [NB100-2823]

Western Blot: TIRAP Antibody [NB100-2823] - Staining (0.3ug/ml) of Human colorectal cancer lysate (35ug protein in RIPA buffer). Detected by chemiluminescence.

Applications for TIRAP Antibody

Application
Recommended Usage

Peptide ELISA

Detection limit 1:32000

Western Blot

0.1 - 0.5 ug/ml
Application Notes
WB: Approx 22-23 kDa band observed in A549, K562 and Human colorectal cancer lysates (calculated MW of 23.9kDa according to NP_001034750.11).

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: TIRAP

The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described.

Alternate Names

adapter protein wyatt, Adaptor protein Wyatt, MAL, MyD88 adapter-like protein, MyD88-2, TIR domain-containing adapter protein, toll/interleukin-1 receptor domain-containing adapter protein, toll-interleukin 1 receptor (TIR) domain containing adaptor protein, Toll-interleukin 1 receptor (TIR) domain-containing adaptor protein, Toll-like receptor adaptor protein, wyatt

Entrez Gene IDs

114609 (Human)

Gene Symbol

TIRAP

UniProt

NP_001034750.1 (Human)

Additional TIRAP Products

Product Documents for TIRAP Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for TIRAP Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Privacy and Cookie Policy
Site Map
© Copyright 2024 Bio-Techne. All Rights Reserved.