TLR2 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB100-56586

Novus Biologicals, part of Bio-Techne
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NB100-56586SS
NB100-56586
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Key Product Details

Species Reactivity

Validated:

Human, Mouse

Cited:

Human

Applications

Validated:

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Cited:

Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

0.5 mg/ml

View all TLR2 Antibodies »

Product Specifications

Immunogen

This antibody was developed against a portion of the extracellular region of mouse TLR2.

Reactivity Notes

Human reactivity reported in scientific literature (PMID: 27370795).

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for TLR2 Antibody

Western Blot: TLR2 Antibody [NB100-56586]

Western Blot: TLR2 Antibody [NB100-56586]

Western Blot: TLR2 Antibody [NB100-56586] - Analysis of mTLR2 in 15 uL / lane of transfected cell lysate using this antibody at 1 ug/mL.

Applications for TLR2 Antibody

Application
Recommended Usage

Immunohistochemistry-Paraffin

reported in scientific literature (PMID 27370795)

Western Blot

0.5-2 ug/ml

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

PBS, 0.2% gelatin

Preservative

0.05% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: TLR2

The Toll-like receptor (TLR) family in mammal comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL-1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules (1). The TLR family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition (2). Ten human homologs of TLRs (TLR1-10) have been described (3). TLR2 is differentially expressed in human cells. TLR2 is expressed in tonsils, lymph nodes, and appendices, activated B-cells in germinal centers. CD14+ monocytes expressed the highest level of TLR2 followed by CD15+ granulocytes, and CD19+ B-cells, CD3+ T-cells, and CD56+ NK cells did not express TLR2. The expression of TLR2 in different cell types is regulated by different immune response modifiers. For example, LPS, GM-CSF, IL-1, and IL-10 up-regulates TLR2 whereas IL-4, IFN-gamma, and TNF down regulate TLR2 expression in monocytes (4).

Long Name

Toll-like Receptor 2

Alternate Names

CD282

Entrez Gene IDs

24088 (Mouse)

Gene Symbol

TLR2

UniProt

NP_003255

Additional TLR2 Products

Product Documents for TLR2 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for TLR2 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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