TMEM41B Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-81552

Novus Biologicals, part of Bio-Techne
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NBP1-81552
NBP1-81552-25ul
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Key Product Details

Species Reactivity

Human

Applications

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all TMEM41B Antibodies »

Product Specifications

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: MAKGRVAERSQLGAHHTTPVGDGAAGTRGLAAPGSRDHQKEKSWVEAGS

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for TMEM41B Antibody

Immunocytochemistry/ Immunofluorescence: TMEM41B Antibody [NBP1-81552]

Immunocytochemistry/ Immunofluorescence: TMEM41B Antibody [NBP1-81552]

Immunocytochemistry/Immunofluorescence: TMEM41B Antibody [NBP1-81552] - Staining of human cell line A-431 shows localization to peroxisomes.
Immunohistochemistry-Paraffin: TMEM41B Antibody [NBP1-81552]

Immunohistochemistry-Paraffin: TMEM41B Antibody [NBP1-81552]

Immunohistochemistry-Paraffin: TMEM41B Antibody [NBP1-81552] - Staining of human Skeletal muscle shows no granular cytoplasmic positivity in myocytes as expected.
Immunohistochemistry-Paraffin: TMEM41B Antibody [NBP1-81552]

Immunohistochemistry-Paraffin: TMEM41B Antibody [NBP1-81552]

Immunohistochemistry-Paraffin: TMEM41B Antibody [NBP1-81552] - Staining of human cerebellum shows strong granular cytoplasmic positivity in Purkinje cells.
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Applications for TMEM41B Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

0.25-2 ug/ml

Immunohistochemistry

1:10-1:500

Immunohistochemistry-Paraffin

1:20-1:50
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended. ICC/IF Fixation Permeabilization: Use PFA/Triton X-100.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: TMEM41B

Transmembrane protein 41B/Stasimon (human TMEM41B theoretical molecular weight 32.5 kDa) is an integral endoplasmic reticulum membrane protein that plays a role in autophagy and neurogenesis (1). TMEM41B forms a complex with vacuole membrane protein 1 (VMP1) and is required for autophagosome formation. Similar to VMP1, TMEM41B contains a VTT domain. Expression of TMEM41B/Stasimon restores motor neuron function defects in Drosophila and zebrafish models of spinal muscular atrophy (SMA). Survival motor neuron protein (SMN) deficiency, which underscores the neuromuscular disorder SMA, affects TMEM41B/Stasimon U12 splicing and mRNA expression (2,3).

1. Stavoe, A. K. H., & Holzbaur, E. L. F. (2019). Autophagy in Neurons. Annual Review of Cell and Developmental Biology. https://doi.org/10.1146/annurev-cellbio-100818-125242

2. Doktor, T. K., Hua, Y., Andersen, H. S., Br0ner, S., Liu, Y. H., Wieckowska, A., Andresen, B. S. (2017). RNA-sequencing of a mouse-model of spinal muscular atrophy reveals tissue-wide changes in splicing of U12-dependent introns. Nucleic Acids Research. https://doi.org/10.1093/nar/gkw731

3. Hosseinibarkooie, S., Schneider, S., & Wirth, B. (2017). Advances in understanding the role of disease-associated proteins in spinal muscular atrophy. Expert Review of Proteomics. https://doi.org/10.1080/14789450.2017.1345631

Long Name

Transmembrane Protein 41B

Alternate Names

KIAA0033, Stasimon

Gene Symbol

TMEM41B

Additional TMEM41B Products

Product Documents for TMEM41B Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for TMEM41B Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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