TNF RII/TNFRSF1B Antibody (R00N6)

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-89487

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP2-89487-200ug
NBP2-89487-500ug
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Key Product Details

Species Reactivity

Human

Applications

Neutralization

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # R00N6

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all TNF RII/TNFRSF1B Antibodies »

Product Specifications

Immunogen

This antibody was obtained from a rabbit immunized with purified, recombinant Human TNF RII/TNFRSF1B (Met 1-Asp 257; Accession#: NP_001057.1).

Specificity

No cross-reactivity in ELISA with: Mouse TNFR2

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Description

This antibody can be stored at 2C-8C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20C to -80C. Avoid repeated freeze-thaw cycles.

Scientific Data Images for TNF RII/TNFRSF1B Antibody (R00N6)

Neutralization: TNF RII/TNFRSF1B Antibody (R00N6) [NBP2-89487]

Neutralization: TNF RII/TNFRSF1B Antibody (R00N6) [NBP2-89487]

Neutralization: TNF RII/TNFRSF1B Antibody (R00N6) [NBP2-89487] - Recombinant Human TNFR2/TNFRSF1B inhibits Recombinant Human TNFa induced cytotoxicity in the L-929 mouse fibroblast cell line. Inhibition of Recombinant Human TNFa (0.25 ng/mL) activity elicited by Recombinant Human TNFR2/TNFRSF1B (1 ug/mL) is neutralized by increasing concentrations of Human TNFR2/TNFRSF1B Monoclonal Antibody. The IC50 is typically 1-3 ug/mL in the presence of the metabolic inhibitor actinomycin D (1 ug/mL).

Applications for TNF RII/TNFRSF1B Antibody (R00N6)

Application
Recommended Usage

Neutralization

Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

0.2 um filtered solution in Histidine and Arginine buffer, 120mM NaCl, 0.02% Tween 80, pH6.0

Preservative

No Preservative

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: TNF RII/TNFRSF1B

Tumor Necrosis Factor (TNF) is a cytokine whose function is mediated through two distinct cell surface receptors (TNF Receptor I and TNF Receptor II) that are included in the TNF receptor superfamily along with FAS antigen and CD40. TNF receptors I and II are 55 and 75 kDa members, respectively, of a family of cell surface molecules including nerve growth factor receptor, Fas/Apo1, CD30, OX40, and 4-1BB, which are characterized by cysteine rich motifs in the extracellular domain. TNF Receptor II (p75, CD120b) is present on most cell types (including monocytes, endothelial cells, Langerhans cells, and macrophages) and is considered to play a role in cell stimulation by TNF alpha. TNF Receptor II molecule is shown to be responsible for stimulation of activated T lymphocytes by TNF alpha.

Long Name

Tumor Necrosis Factor Receptor II

Alternate Names

CD120b, TNFRII, TNFRSF1B

Gene Symbol

TNFRSF1B

Additional TNF RII/TNFRSF1B Products

Product Documents for TNF RII/TNFRSF1B Antibody (R00N6)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for TNF RII/TNFRSF1B Antibody (R00N6)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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