Topo III beta Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-17775

Novus Biologicals, part of Bio-Techne
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NBP3-17775-100ul
NBP3-17775-25ul
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Mouse (97%), Rat (96%). Backed by our 100% Guarantee.

Applications

Immunocytochemistry/ Immunofluorescence

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Topo III beta Antibodies »

Product Specifications

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: TIKLYKELRCPLDDFELVLWSSGSRGKSYPLCPYCYNHPPFRDMKKGMGCNECTHPSCQHSLSMLGIGQCVECESGVLVLDPTSGPKWKVACNKCNVV

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Topo III beta Antibody

Immunocytochemistry/ Immunofluorescence: Topo III beta Antibody [NBP3-17775]

Immunocytochemistry/ Immunofluorescence: Topo III beta Antibody [NBP3-17775]

Immunocytochemistry/Immunofluorescence: Topo III beta Antibody [NBP3-17775] - Staining of human cell line HaCaT shows localization to nucleoplasm.

Applications for Topo III beta Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

0.25-2 ug/ml
Application Notes
ICC/IF, PFA/Triton X-100 is recommended for fixation/permeabilization.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, pH 7.2, 40% glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Topo III beta

Topo III beta encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus relaxing the supercoils and altering the topology of DNA. The enzyme interacts with DNA helicase SGS1 and plays a role in DNA recombination, cellular aging and maintenance of genome stability. Alternative splicing of the C-terminus of this gene results in three transcript variants which have distinct tissue specificity; however, not all variants have been fully described.

Alternate Names

DNA topoisomerase 3-beta-1, DNA topoisomerase III beta-1, EC 5.99.1.2, FLJ39376, TOP3B1, topoisomerase (DNA) III beta, topoisomerase III beta

Gene Symbol

TOP3B

Additional Topo III beta Products

Product Documents for Topo III beta Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Topo III beta Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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