TR alpha/NR1A1/Thyroid Hormone Receptor alpha Antibody (1718)

Novus Biologicals, part of Bio-Techne | Catalog # NB200-318

Novus Biologicals, part of Bio-Techne
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Key Product Details

Species Reactivity

Validated:

Human, Rat

Predicted:

Canine (100%), Mouse (100%), Primate (100%). Backed by our 100% Guarantee.

Applications

Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG2A Clone # 1718

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all TR alpha/NR1A1 Antibodies »

Product Specifications

Immunogen

Synthetic peptide corresponding to amino acid residues from the N-terminal region conjugated to KLH. Accession # P10827

Reactivity Notes

It is anticipated that the antibody will react with canine, mouse and non-human primates based on the fact that these species have 100% homology with the amino acid sequence used as antigen.

Specificity

Specific for endogenous levels of the ~50 kDa TR-alpha1 and the ~58 kDa TR-alpha2 proteins.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2A

Theoretical MW

50 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for TR alpha/NR1A1/Thyroid Hormone Receptor alpha Antibody (1718)

Western Blot: TR alpha/NR1A1/Thyroid Hormone Receptor alpha Antibody (1718) [NB200-318]

Western Blot: TR alpha/NR1A1/Thyroid Hormone Receptor alpha Antibody (1718) [NB200-318]

Western Blot: TR alpha/NR1A1/Thyroid Hormone Receptor alpha Antibody (1718) [NB200-318] - Western blot analysis of Thyroid Hormone Receptor alpha in brain lysate using NB200-318 at 1:1000.
Western Blot: TR alpha/NR1A1/Thyroid Hormone Receptor alpha Antibody (1718) [NB200-318]

Western Blot: TR alpha/NR1A1/Thyroid Hormone Receptor alpha Antibody (1718) [NB200-318]

Western Blot: TR alpha/NR1A1/Thyroid Hormone Receptor alpha Antibody (1718) [NB200-318] - Detection of human TH Receptor alpha 1 and alpha 2 using NB 200-318.
Western Blot: TR alpha/NR1A1/Thyroid Hormone Receptor alpha Antibody (1718) [NB200-318]

Western Blot: TR alpha/NR1A1/Thyroid Hormone Receptor alpha Antibody (1718) [NB200-318]

Western Blot: TR alpha/NR1A1/Thyroid Hormone Receptor alpha Antibody (1718) [NB200-318] - Western blot of rat hippocampal lysate showing specific immunolabeling of the ~50k TR-alpha-1 and the ~58k TR-alpha-2 protein.

Applications for TR alpha/NR1A1/Thyroid Hormone Receptor alpha Antibody (1718)

Application
Recommended Usage

Western Blot

1:1000
Application Notes
The investigator should determine the optimal working dilution for a specific application.

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

10mM HEPES (pH 7.5), 0.15M NaCl, 0.1 mg/ml BSA and 50% Glycerol

Preservative

No Preservative

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: TR alpha/NR1A1

Thyroid hormones regulate general metabolism and normal cellular growth and development. These actions are regulated by the thyroid hormone receptor (TR), a ligand-dependent transcriptional factor. At least two genes and several isoforms encode TR. Recent studies have implicated a role of TRs in thyroid hormone-induced apoptosis in larval tissues and proliferation of adult cell types (1-3).

Long Name

Thyroid Hormone Receptor alpha

Alternate Names

NR1A1, THRA, v-ErbA1

Gene Symbol

THRA

UniProt

P10827 (Human)

Additional TR alpha/NR1A1 Products

Product Documents for TR alpha/NR1A1/Thyroid Hormone Receptor alpha Antibody (1718)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for TR alpha/NR1A1/Thyroid Hormone Receptor alpha Antibody (1718)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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