TRAF-1 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB100-56170

Novus Biologicals, part of Bio-Techne
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NB100-56170
NB100-56170SS
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Key Product Details

Species Reactivity

Validated:

Human, Bovine, Canine

Cited:

Human

Applications

Validated:

Immunohistochemistry, Immunohistochemistry-Paraffin, Immunoprecipitation, Western Blot

Cited:

Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

This product is unpurified. The exact concentration of antibody is not quantifiable.

View all TRAF-1 Antibodies »

Product Specifications

Immunogen

A synthetic peptide corresponding to amino acids between 1 and 50 of human TRAF1 was used as immunogen, GenBank no. NP_005649.1.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for TRAF-1 Antibody

Western Blot: TRAF-1 Antibody [NB100-56170]

Western Blot: TRAF-1 Antibody [NB100-56170]

Western Blot: TRAF-1 Antibody [NB100-56170] - Analysis of TRAF-1 in normal human tissues using this antibody. TRAF-1 is observed at 50-50 kDa. Additional bands of lower molecular weight were seen in some cases, and may represent TRAF-1 degradation fragments.
Immunohistochemistry-Paraffin: TRAF-1 Antibody [NB100-56170]

Immunohistochemistry-Paraffin: TRAF-1 Antibody [NB100-56170]

Immunohistochemistry-Paraffin: TRAF-1 Antibody [NB100-56170] - Formalin-fixed, paraffin-embedded human tissue sections stained for TRAF-1 expression using NB100-56170 at 1:2000. Hematoxylin-eosin counterstain. A, A1: Formalin-fixed, paraffin-embedded human lymphoma tissue section stained for TRAF-1 expression using NB100-56170 at 1:2000. Hematoxylin-eosin counterstain. A, Hodgkin'sDisease, the Reed-Sternberg cells are positive for TRAF-1 expression. B, lymph node, dendritic-like cells are positive for TRAF-1 expression. A1 and B1 are higher magnifications from A and B, respectively.
Immunohistochemistry-Paraffin: TRAF-1 Antibody [NB100-56170]

Immunohistochemistry-Paraffin: TRAF-1 Antibody [NB100-56170]

Immunohistochemistry-Paraffin: TRAF-1 Antibody [NB100-56170] - Formalin-fixed, paraffin-embedded human lymphoma tissue section stained for TRAF-1 expression using NB100-56170 at 1:2000. Hematoxylin-eosin counterstain. A1 is a higher magnification of A.

Applications for TRAF-1 Antibody

Application
Recommended Usage

Immunohistochemistry-Paraffin

1:1000-1:5000

Immunoprecipitation

1:50-1:200

Western Blot

1:1000-1:2000

Formulation, Preparation, and Storage

Purification

Unpurified

Formulation

Neat whole antisera

Preservative

0.02% Sodium Azide

Concentration

This product is unpurified. The exact concentration of antibody is not quantifiable.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: TRAF-1

The TRAF (TNF receptor-associated factor) family is a group of adapter proteins (TRAFs 1-6) that link a wide variety of cell surface receptors to diverse signaling cascades leading to the activation of NF-kB and mitogen-activated protein kinases (reviewed in Chung et al, 2002). TRAFs are major signal transducers for both the TNF and IL- 1/TLR receptor superfamilies and collectively play important functions in both adaptive and innate immunity. The carboxy-terminal region of TRAFs is required for self-association and interaction with receptor cytoplasmic domains following ligand-induced oligomerization. TRAFs interact with a variety of proteins that regulate receptor-induced cell death or survival, and TRAF-mediated signaling can promote cell survival or interfere with death receptor-induced apoptosis. This antibody recognizes TRAF1; human TRAF1 is a 416 amino acid protein.

Long Name

TNF Receptor-Associated Factor 1

Alternate Names

EBI6, TRAF1

Entrez Gene IDs

7185 (Human)

Gene Symbol

TRAF1

Additional TRAF-1 Products

Product Documents for TRAF-1 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for TRAF-1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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