TRAF-5 Antibody (55A219)

Novus Biologicals, part of Bio-Techne | Catalog # NB600-1107

Novus Biologicals, part of Bio-Techne

Key Product Details

Species Reactivity

Human

Applications

Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG Clone # 55A219

Concentration

0.5 mg/ml

View all TRAF-5 Antibodies »

Product Specifications

Immunogen

Anti-TRAF5 monoclonal antibody was raised against a fusion protein corresponding to amino acids 77 to 186 of human TRAF5.

Reactivity Notes

Not yet tested in other species.

Localization

Cytoplasmic (probable)

Clonality

Monoclonal

Host

Mouse

Isotype

IgG

Scientific Data Images for TRAF-5 Antibody (55A219)

Western Blot: TRAF-5 Antibody (55A219) [NB600-1107]

Western Blot: TRAF-5 Antibody (55A219) [NB600-1107]

Western Blot: TRAF-5 Antibody (55A219) [NB600-1107] - Analysis of TRAF-5 using this antibody at 2 ug/ml dilution against 10 ug of HeLa cell lysate.

Applications for TRAF-5 Antibody (55A219)

Application
Recommended Usage

Western Blot

2 ug/ml
Application Notes
A 66 kDa band is seen in Western Blot (predicted molecular weight 66.8 kDa).

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

PBS containing 0.05% BSA

Preservative

0.05% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: TRAF-5

Tumor necrosis factor (TNF) induced signaling is mediated through association of TNF receptor (TNFR) with adaptor proteins, such as TNF receptor associated proteins (TRAFs). TRAFs form a family of cytoplasmic adapter proteins that mediate signal transduction from many members of the TNF-receptor superfamily (e.g. RANK, CD30, CD40, etc.) and the interleukin-1 receptor. The carboxy-terminal region of TRAFs is required for self-association and interaction with receptor cytoplasmic domains following ligand-induced oligomerization. Recent molecular cloning studies have lead to identification of six TRAFs (TRAF1-TRAF6). TRAF5 is a 558-amino acid protein. TRAF5 is implicated in NF-kB and c-Jun NH(2)-terminal kinase/stress-activated protein kinase activation by members of the TNF receptor superfamily, including CD27, CD30, CD40, and lymphotoxin-beta receptor . Targeted disruption of TRAF5 gene causes defects in CD40-CD27 mediated lymhocyte activation.

Long Name

TNF Receptor-Associated Factor 5

Alternate Names

RNF84, TRAF5

Entrez Gene IDs

7188 (Human)

Gene Symbol

TRAF5

UniProt

O00463 (Human)

Additional TRAF-5 Products

Product Documents for TRAF-5 Antibody (55A219)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for TRAF-5 Antibody (55A219)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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