TRAILR1/TNFRSF10A Antibody (32A242) - Azide Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-27415

Novus Biologicals, part of Bio-Techne

Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat

Cited:

Human

Applications

Validated:

Western Blot

Cited:

Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 Clone # 32A242

Format

Azide Free

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all TRAILR1/TNFRSF10A Antibodies »

Product Specifications

Immunogen

This monoclonal antibody was raised against a peptide corresponding to amino acid 2 to 21 of human DR4.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Scientific Data Images for TRAILR1/TNFRSF10A Antibody (32A242) - Azide Free

Western Blot: TRAILR1/TNFRSF10A Antibody (32A242)Azide Free [NBP2-27415]

Western Blot: TRAILR1/TNFRSF10A Antibody (32A242)Azide Free [NBP2-27415]

Western Blot: TRAILR1/TNFRSF10A Antibody (32A242) - Azide Free [NBP2-27415] - Analysis of 20 ug of total cell lysate from HeLa cells with DR4 antibody at 2 ug/ml. Goat anti-mouse Ig HRP secondary antibody and PicoTect ECL substrate solution were used for this test.

Applications for TRAILR1/TNFRSF10A Antibody (32A242) - Azide Free

Application
Recommended Usage

Western Blot

1-3ug/ml
Application Notes
In HeLa, a 57 kDa band should be observed.

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

0.2 ml sterile PBS

Format

Azide Free

Preservative

No Preservative

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: TRAILR1/TNFRSF10A

Cells undergo programmed cell death in response to various stimuli. Apoptosis is essential for morphogenesis, tissue homeostasis, and host defense (5). It is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors, TNFR1 and Fas. A death domain containing receptor was identified and designated DR4 (4). The ligand for this death receptor has been identified and termed TRAIL (2,3), which is a new member in the TNF family. DR4 is also called TRAIL receptor-1 (TRAILR1) (1). DR4 is expressed in most human tissues including spleen, peripheral blood leukocytes, small intestine and thymus. Like TNFR1, Fas and DR3, DR4 mediates apoptosis and NF-kB activation in many tissues and cells.

Long Name

TRAIL Receptor 1

Alternate Names

CD261, DR4, TNFRSF10A, TRAIL R1

Gene Symbol

TNFRSF10A

Additional TRAILR1/TNFRSF10A Products

Product Documents for TRAILR1/TNFRSF10A Antibody (32A242) - Azide Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for TRAILR1/TNFRSF10A Antibody (32A242) - Azide Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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