TRAILR1/TNFRSF10A Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-33716

Novus Biologicals, part of Bio-Techne
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NBP2-33716
NBP2-33716-25ul
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Key Product Details

Species Reactivity

Validated:

Human

Applications

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all TRAILR1/TNFRSF10A Antibodies »

Product Summary for TRAILR1/TNFRSF10A Antibody

Immunogen

This antibody was developed against a recombinant protein corresponding to amino acids: PSSAATIKLHDQSIGTQQWEHSPLGELCPPGSHRS

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for TRAILR1/TNFRSF10A Antibody

Immunocytochemistry/ Immunofluorescence: TRAILR1/TNFRSF10A Antibody [NBP2-33716]

Immunocytochemistry/ Immunofluorescence: TRAILR1/TNFRSF10A Antibody [NBP2-33716]

Immunocytochemistry/Immunofluorescence: TRAILR1/TNFRSF10A Antibody [NBP2-33716] - Immunofluorescent staining of human cell line A549 shows localization to nucleus.
Immunohistochemistry-Paraffin: TRAILR1/TNFRSF10A Antibody [NBP2-33716]

Immunohistochemistry-Paraffin: TRAILR1/TNFRSF10A Antibody [NBP2-33716]

Immunohistochemistry-Paraffin: TRAILR1/TNFRSF10A Antibody [NBP2-33716] - Staining of human skeletal muscle shows no positivity in myocytes as expected.
Immunohistochemistry-Paraffin: TRAILR1/TNFRSF10A Antibody [NBP2-33716]

Immunohistochemistry-Paraffin: TRAILR1/TNFRSF10A Antibody [NBP2-33716]

Immunohistochemistry-Paraffin: TRAILR1/TNFRSF10A Antibody [NBP2-33716] - Staining of human small intestine shows moderate cytoplasmic positivity in glandular cells.
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Applications for TRAILR1/TNFRSF10A Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

0.25-2 ug/ml

Immunohistochemistry

1:50 - 1:200

Immunohistochemistry-Paraffin

1:50 - 1:200
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended. Immunocytochemistry/Immunofluorescence Fixation Permeabilization: Use PFA/Triton X-100.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: TRAILR1/TNFRSF10A

TRAIL-R1 (CD261, DR4) is a type I transmembrane protein, also called TRAIL receptor 1. The ligand for this DR4 death receptor has been identified and termed TRAIL, which is a member of the TNF family. DR4, as many other receptors (Fas, TNFR1, etc.), mediates apoptosis and NF kappaB activation in many cells and tissues. Apoptosis, a programmed cell death, is a operating process in normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by coupled of certain cytokines (TNF family - TNF, Fas ligand) and their death domain containing receptors (TNFR1, Fas receptor).

Long Name

TRAIL Receptor 1

Alternate Names

CD261, DR4, TNFRSF10A, TRAIL R1

Gene Symbol

TNFRSF10A

UniProt

O00220 (Human)

Additional TRAILR1/TNFRSF10A Products

Product Documents for TRAILR1/TNFRSF10A Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for TRAILR1/TNFRSF10A Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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