TRAM/TICAM2 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-24638

Novus Biologicals, part of Bio-Techne
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NBP2-24638
NBP2-24638SS
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Key Product Details

Species Reactivity

Validated:

Human, Primate

Predicted:

Chimpanzee (100%), Monkey (100%), Mouse (93%), Rat (93%), Rhesus Macaque (100%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

0.5 mg/ml

View all TRAM/TICAM2 Antibodies »

Product Specifications

Immunogen

Within the range of amino acids 87-124 of human TRAM (TICAM2) protein were used as the immunogen.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for TRAM/TICAM2 Antibody

Western Blot: TRAM/TICAM2 Antibody [NBP2-24638]

Western Blot: TRAM/TICAM2 Antibody [NBP2-24638]

Western Blot: TRAM/TICAM2 Antibody [NBP2-24638] - Lysate from human lung in the 1) absence, 2) presence of immunizing peptide, 3) mouse lung and 4) rat lung probed with TRAM antibody at 1 ug/ml. Goat anti-rabbit Ig HRP secondary antibody and PicoTect ECL substrate solution were used for this test.
Immunohistochemistry-Paraffin: TRAM/TICAM2 Antibody [NBP2-24638]

Immunohistochemistry-Paraffin: TRAM/TICAM2 Antibody [NBP2-24638]

Immunohistochemistry-Paraffin: TRAM/TICAM2 Antibody [NBP2-24638] - Staining of human brain tissue probed with an isotype control antibody (top left) and TRAM antibody (bottom left, right) at 5 ug/ml.

Applications for TRAM/TICAM2 Antibody

Application
Recommended Usage

Immunohistochemistry-Paraffin

5 ug/ml

Western Blot

0.5-2 ug/ml

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

0.2 ml PBS and 0.05% BSA

Preservative

0.05% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: TRAM/TICAM2

TIRP is a member of the Toll/interleukin-1 receptor (TIR) family, a group of proteins that include the Toll-like receptors (TLRs) (1-3). TLRs are signaling molecules that recognize different pathogen-associated molecular patterns (PAMPs) and serve as an important link between the innate and adaptive immune responses (4). TIRP, along with other molecules such as TRIF, MAL, and MyD88, serves as an adaptor protein that allows for the interaction and activation of the IL-1R-associated kinase (IRAK) family, the subsequent activation of TNF receptor associated factor (TRAF)-6, and ultimately the activation of NF-kappaB (5). Expression of TIRP appears to be essential for TLR4 signalling (6).

Long Name

TRIF-related Adapter Molecule

Alternate Names

TICAM2, TIRAP3, TIRP, Trif

Gene Symbol

TICAM2

UniProt

Q86XR7 (Human)

Additional TRAM/TICAM2 Products

Product Documents for TRAM/TICAM2 Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for TRAM/TICAM2 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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