TRANCE/TNFSF11/RANK L Antibody (IK22-5) [Biotin]

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-81123B

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP2-81123B
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Key Product Details

Species Reactivity

Validated:

Mouse

Applications

Flow Cytometry, Immunohistochemistry, Neutralization

Label

Biotin

Antibody Source

Recombinant Monoclonal Rabbit IgG Kappa Clone # IK22-5

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all TRANCE/TNFSF11/RANK L Antibodies »

Product Summary for TRANCE/TNFSF11/RANK L Antibody (IK22-5) [Biotin]

Immunogen

Thus antibody was raised by immunising an SD rat with murine TRANCE/TNFSF11/RANK L-transfected baby hamster kidney cells.

Specificity

This antibody is specific for murine TRANCE/TNFSF11/RANK L.

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG Kappa

Applications for TRANCE/TNFSF11/RANK L Antibody (IK22-5) [Biotin]

Application
Recommended Usage

Flow Cytometry

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry

Optimal dilutions of this antibody should be experimentally determined.

Neutralization

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Optimal dilution of this antibody should be experimentally determined.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

PBS

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: TRANCE/TNFSF11/RANK L

TRANCE/OPGL/RANKL/ODF is a recently identified member of tumor necrosis factor family. TRANCE (TNF-related activation-induced cytokine receptor) or RANKL {receptor activator of NF-kB (RANK) ligand} has been implicated in interactions between T cells and dendritic cells (1-2). RANK ligand (RANKL/TRANCE) binds to RANK on dendritic cells, upregulates the expression of anti-apoptotic protein BcL-XL suggesting a role in dendritic cell survival (2). TRANCE/RANKL is also important in T and B-cell maturation (3). As OPGL/ODF (Osteoprotegerin Ligand/Osteoclast differentiation factor), the same protein can both activate mature osteoclasts and mediate osteoclastogenesis (4). OPGL/TRANCE deficient mice show severe osteoporesis and complete absence of osteoclasts as a result of lack of osteogenesis (3).

Long Name

TNF-related Activation-induced Cytokine

Alternate Names

CD254, ODF, OPGL, RANK L, RANKL, TNFSF11

Gene Symbol

TNFSF11

Additional TRANCE/TNFSF11/RANK L Products

Product Documents for TRANCE/TNFSF11/RANK L Antibody (IK22-5) [Biotin]

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for TRANCE/TNFSF11/RANK L Antibody (IK22-5) [Biotin]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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