TRANCE/TNFSF11/RANK L Antibody - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NB100-80849

Novus Biologicals, part of Bio-Techne
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NB100-80849
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Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat

Cited:

Human, Mouse, Rat

Applications

Validated:

ELISA, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Cited:

IF/IHC, Immunocytochemistry/ Immunofluorescence

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

1 mg/ml

View all TRANCE/TNFSF11/RANK L Antibodies »

Product Specifications

Immunogen

A 14 aa synthetic peptide near the center of human TRANCE/TNFSF11/RANK L. The immunogen is located within aa 140 - 190 of TRANCE/TNFSF11/RANK L.

Epitope

Near the center, aa 140-190

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for TRANCE/TNFSF11/RANK L Antibody - BSA Free

Western Blot: TRANCE/TNFSF11/RANK L AntibodyBSA Free [NB100-80849]

Western Blot: TRANCE/TNFSF11/RANK L AntibodyBSA Free [NB100-80849]

Western Blot: TRANCE/TNFSF11/RANK L Antibody - BSA Free [NB100-80849] - Rat liver tissue lysate with sRANK-L antibody at (A) 0.25 and (B) 0.5 ug/ml.
Immunohistochemistry-Paraffin: TRANCE/TNFSF11/RANK L Antibody - BSA Free [NB100-80849]

Immunohistochemistry-Paraffin: TRANCE/TNFSF11/RANK L Antibody - BSA Free [NB100-80849]

Immunohistochemistry-Paraffin: TRANCE/TNFSF11/RANK L Antibody - BSA Free [NB100-80849] - Staining of human small intestine tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Immunohistochemistry-Paraffin: TRANCE/TNFSF11/RANK L Antibody - BSA Free [NB100-80849]

Immunohistochemistry-Paraffin: TRANCE/TNFSF11/RANK L Antibody - BSA Free [NB100-80849]

Immunohistochemistry-Paraffin: TRANCE/TNFSF11/RANK L Antibody - BSA Free [NB100-80849] - Staining of human breast tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.

Applications for TRANCE/TNFSF11/RANK L Antibody - BSA Free

Application
Recommended Usage

Immunohistochemistry

5 ug/ml

Immunohistochemistry-Paraffin

5 ug/ml

Western Blot

0.25-0.5 ug/ml
Application Notes
Use in ICC/IF reported in scientific literature (PMID: 29524829)..

Formulation, Preparation, and Storage

Purification

Peptide affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: TRANCE/TNFSF11/RANK L

RANKL is a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. There are three isoforms of RANKL. Human RANKL is a soluble 20 kDa polypeptide, comprising the TNF homologous region of RANKL (176 amino acid residues). This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor associated factor (TRAF) 6, which indicated that this protein may have a role in the regulation of cell apoptosis. RANKL deficient mice show severe osteoporesis and complete absence of osteoclasts as a result of lack of osteogenesis.

Long Name

TNF-related Activation-induced Cytokine

Alternate Names

CD254, ODF, OPGL, RANK L, RANKL, TNFSF11

Entrez Gene IDs

21943 (Mouse); 117516 (Rat)

Gene Symbol

TNFSF11

UniProt

O14788

Additional TRANCE/TNFSF11/RANK L Products

Product Documents for TRANCE/TNFSF11/RANK L Antibody - BSA Free

Product Datasheets

Certificate of Analysis

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Product Specific Notices for TRANCE/TNFSF11/RANK L Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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