TREK 1 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB110-41535

Novus Biologicals, part of Bio-Techne

Key Product Details

Species Reactivity

Human, Mouse, Bovine

Applications

Validated:

ICC/IF (Negative), Immunohistochemistry (Negative), Western Blot

Cited:

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

1 mg/ml

View all TREK 1 Antibodies »

Product Specifications

Immunogen

A synthetic peptide made to an N-terminal region of human TREK 1 (within residues 1-100). [Swiss-Prot# Q9NRT2]

Reactivity Notes

88% sequence identity with rat protein.

Localization

Membrane

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for TREK 1 Antibody

Western Blot: TREK 1 Antibody [NB110-41535]

Western Blot: TREK 1 Antibody [NB110-41535]

Western Blot: TREK 1 Antibody [NB110-41535] - Detection of TREK 1 in membrane lysate fraction of human brain tissue.

Applications for TREK 1 Antibody

Application
Recommended Usage

Western Blot

1:1000
Application Notes
This TREK 1 antibody is useful inThis TREK 1 antibody is useful for Western Blot where a band is seen ~47 kDa. Please note that it is essential to run against membrane preps. This antibody is not recommended for Immunohistochemistry or Immunocytochemisrty.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Background: TREK 1

TREK 1 (KCNK2 or two pore potassium channel TPKC1) belongs to two pore domain potassium channel (TC 1.A.1.8) family and it is a TWIK related K+ channel that acts as a background channel producing time/voltage-independent background current which drives the membrane potential toward the K+ equilibrium potential thereby affecting input resistance. TREK1 is characterized by mechanosensitivity, heat sensitivity, G-protein regulation, and activation by lipids, arachidonic acid, and volatile anesthetics such as chloroform, halothane and isoflurane. TREK1 is widely expressed in brain and genetic ablation has revealed involvement of this channel in depression, neuroprotection, pain perception, and ischemia-precipitated epilepsy. TREK1 gene inactivation produces mice with decreased sensitivity to volatile anesthetics, impaired PUFA-mediated neuroprotection and altered pain perception, depression-resistant phenotype and alteration in the efficacy of GPCR-associated cascade producing NO that leads to major endothelial dysfunction.

Long Name

Potassium channel subfamily K member 2

Alternate Names

KCNK2, TREK, TREK1

Gene Symbol

KCNK2

Additional TREK 1 Products

Product Documents for TREK 1 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for TREK 1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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