Tripeptidyl-Peptidase I/TPP1 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-48820

Novus Biologicals, part of Bio-Techne
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NBP2-48820
NBP2-48820-25ul
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Key Product Details

Validated by

Orthogonal Validation, Independent Antibodies

Species Reactivity

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Tripeptidyl-Peptidase I/TPP1 Antibodies »

Product Specifications

Immunogen

This antibody was developed against a recombinant protein corresponding to amino acids: SSLRQRPEPQVTGTVGLHLGVTPSVIRKRYNLTSQDVGSGTSNNSQACAQFLEQYFHDSDLAQFMRLFGGNFAHQASVARVV

Reactivity Notes

Mouse (82%), Rat (83%)

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Tripeptidyl-Peptidase I/TPP1 Antibody

Immunohistochemistry-Paraffin: Tripeptidyl-Peptidase I/TPP1 Antibody [NBP2-48820]

Immunohistochemistry-Paraffin: Tripeptidyl-Peptidase I/TPP1 Antibody [NBP2-48820]

Immunohistochemistry-Paraffin: Tripeptidyl-Peptidase I/TPP1 Antibody [NBP2-48820] - Staining of human kidney.
Immunohistochemistry: Tripeptidyl-Peptidase I/TPP1 Antibody [NBP2-48820]

Immunohistochemistry: Tripeptidyl-Peptidase I/TPP1 Antibody [NBP2-48820]

Immunohistochemistry: Tripeptidyl-Peptidase I/TPP1 Antibody [NBP2-48820] - Staining of human heart muscle shows strong granular cytoplasmic positivity in myocytes.
Immunohistochemistry: Tripeptidyl-Peptidase I/TPP1 Antibody [NBP2-48820]

Immunohistochemistry: Tripeptidyl-Peptidase I/TPP1 Antibody [NBP2-48820]

Immunohistochemistry: Tripeptidyl-Peptidase I/TPP1 Antibody [NBP2-48820] - Staining of human adrenal gland shows high expression.
View 4 more images

Applications for Tripeptidyl-Peptidase I/TPP1 Antibody

Application
Recommended Usage

Immunohistochemistry

1:500 - 1:1000

Immunohistochemistry-Paraffin

1:500 - 1:1000
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Tripeptidyl-Peptidase I/TPP1

TPP1 encodes a member of the sedolisin family of serine proteases. The protease functions in the lysosome to cleave N-terminal tripeptides from substrates, and has weaker endopeptidase activity. It is synthesized as a catalytically-inactive enzyme which is activated and auto-proteolyzed upon acidification. Mutations in this gene result in late-infantile neuronal ceroid lipofuscinosis, which is associated with the failure to degrade specific neuropeptides and a subunit of ATP synthase in the lysosome.

Alternate Names

CLN2, LINCL, LPIC, TPP1, TripeptidylPeptidase I

Gene Symbol

TPP1

Additional Tripeptidyl-Peptidase I/TPP1 Products

Product Documents for Tripeptidyl-Peptidase I/TPP1 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Tripeptidyl-Peptidase I/TPP1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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