TrkA Antibody (2A5) - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-26455

Recombinant monoclonal antibody expressed in HEK293F cells
Novus Biologicals, part of Bio-Techne
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Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

ELISA, Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # 2A5

Format

BSA Free

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all TrkA Antibodies »

Product Specifications

Immunogen

A synthesized peptide derived from Human TrkA [UniProt P04629]

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for TrkA Antibody (2A5) - BSA Free

TrkA Antibody (2A5)

Western Blot: TrkA Antibody (2A5) [NBP3-26455] -

Western Blot: TrkA Antibody (2A5) [NBP3-26455] - Positive Western Blot detected in: Rat Brain whole cell lysate, Mouse Brain whole cell lysate.
All lanes: TrkA Antibody at 1: 1000
Secondary: Goat polyclonal to rabbit IgG at 1/50000 dilution.
Predicted band size: 88, 87, 84, 78 kDa
Observed band size: 145 kDa

Applications for TrkA Antibody (2A5) - BSA Free

Application
Recommended Usage

Western Blot

1:500-1:5000

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, pH 7.4, 150mM NaCl, and 50% glycerol

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20 to -70C. Avoid freeze-thaw cycles.

Background: TrkA

The Trk proto-oncogene encodes a 140 kDa, membrane-spanning protein tyrosine kinase that is expressed only in neural tissues. Nerve growth factor (NGF) stimulates phosphorylation of Trk A in neural cell lines and in embryonic dorsal root ganglia. Affinity cross-linking and equilibrium binding experiments with 125I-labeled NGF indicate that Trk A binds NGF specifically in cultured cells with a dissociation constant of 10(-9) molar. The identification of Trk A as an NGF receptor indicates that this protein participates in the primary signal transduction mechanism of NGF (1). Trk A was found to be expressed in the nervous system and phosphorylated in response to NGF (Nerve Growth Factor). Somatic rearrangement(s) of the TRKA gene (also designated NTRK1) are responsible for formation of some oncogenes (2). Trk A is expressed in neural and nonneuronal tissues. Like RET, Trk A is often activated by rearrangements that involve one of at least five other genes in papillary thyroid carcinoma (PTC) (3).

Long Name

Neurotrophic Tyrosine Kinase Receptor A

Alternate Names

NTRK-1, NTRK1

Gene Symbol

NTRK1

Additional TrkA Products

Product Documents for TrkA Antibody (2A5) - BSA Free

Product Datasheets

Certificate of Analysis

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Product Specific Notices for TrkA Antibody (2A5) - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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