TrkA Antibody (MNAC13) [CoraFluor™ 1]

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-81074CL1

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Product Datasheet / COA / SDS

Recombinant Monoclonal Antibody

View Available Conjugates View Available Formulations

Conjugate

Catalog #

Alexa Fluor 350

NBP2-81074AF350

Alexa Fluor 405

NBP2-81074AF405

Alexa Fluor 488

NBP2-81074AF488

Alexa Fluor 532

NBP2-81074AF532

Alexa Fluor 594

NBP2-81074AF594

Alexa Fluor 647

NBP2-81074AF647

Alexa Fluor 700

NBP2-81074AF700

Alexa Fluor 750

NBP2-81074AF750

Biotin

NBP2-81074B

DyLight 350

NBP2-81074UV

DyLight 405

NBP2-81074V

DyLight 488

NBP2-81074G

DyLight 550

NBP2-81074R

DyLight 594

NBP2-81074DL594

DyLight 650

NBP2-81074C

DyLight 680

NBP2-81074FR

DyLight 755

NBP2-81074IR

FITC

NBP2-81074F

HRP

NBP2-81074H

Janelia Fluor 525

NBP2-81074JF525

Janelia Fluor 549

NBP2-81074JF549

Janelia Fluor 646

NBP2-81074JF646

Janelia Fluor 669

NBP2-81074JF669

mFluor Violet 450 SE

NBP2-81074MFV450

mFluor Violet 500 SE

NBP2-81074MFV500

mFluor Violet 610 SE

NBP2-81074MFV610

PerCP

NBP2-81074PCP

Forumulation

Catalog #

Azide and BSA Free

NBP2-81074

Product Specifications
Applications
Preparation & Storage
Background
Product Documents
Specific Notices

Key Product Details

Species Reactivity

Human

Applications

Block/Neutralize, ELISA, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Surface Plasmon Resonance

Label

CoraFluor 1

Antibody Source

Recombinant Monoclonal Rabbit IgG Kappa Clone # MNAC13

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all TrkA Antibodies »

Product Specifications

Immunogen

Human TrkA ECD.

Specificity

This antibody binds to the extracellular domain of TrkA. It was shown not to cross react with TrkB . Moreover MNAC13 is specific to TrkA with negligible reactivity to TrkB and TrkC.

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG Kappa

Description

CoraFluor(TM) 1 is a high performance terbium-based TR-FRET (Time-Resolved Fluorescence Resonance Energy Transfer) or TRF (Time-Resolved Fluorescence) donor for high throughput assay development. CoraFluor(IM) 1 absorbs UV light at approximately 340 nm, and emits at approximately 490 nm, 545 nm, 585 nm and 620 nm. It is compatible with common acceptor dyes that absorb at the emission wavelengths of CoraFluor(TM) 1. CoraFluor(TM) 1 can be used for the development of robust and scalable TR-FRET binding assays such as target engagement, ternary complex, protein-protein interaction and protein quantification assays.

Applications for TrkA Antibody (MNAC13) [CoraFluor™ 1]

Application

Recommended Usage

Block/Neutralize

Optimal dilutions of this antibody should be experimentally determined.

ELISA

Optimal dilutions of this antibody should be experimentally determined.

Immunocytochemistry/ Immunofluorescence

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry

Optimal dilutions of this antibody should be experimentally determined.

Surface Plasmon Resonance

Optimal dilutions of this antibody should be experimentally determined.

Application Notes

Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

PBS

Preservative

No Preservative

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark. Do not freeze.

Background: TrkA

The Trk proto-oncogene encodes a 140 kDa, membrane-spanning protein tyrosine kinase that is expressed only in neural tissues. Nerve growth factor (NGF) stimulates phosphorylation of Trk A in neural cell lines and in embryonic dorsal root ganglia. Affinity cross-linking and equilibrium binding experiments with 125I-labeled NGF indicate that Trk A binds NGF specifically in cultured cells with a dissociation constant of 10(-9) molar. The identification of Trk A as an NGF receptor indicates that this protein participates in the primary signal transduction mechanism of NGF (1). Trk A was found to be expressed in the nervous system and phosphorylated in response to NGF (Nerve Growth Factor). Somatic rearrangement(s) of the TRKA gene (also designated NTRK1) are responsible for formation of some oncogenes (2). Trk A is expressed in neural and nonneuronal tissues. Like RET, Trk A is often activated by rearrangements that involve one of at least five other genes in papillary thyroid carcinoma (PTC) (3).

Long Name

Neurotrophic Tyrosine Kinase Receptor A

Alternate Names

NTRK-1, NTRK1

Gene Symbol

NTRK1

Additional TrkA Products

Product Documents for TrkA Antibody (MNAC13) [CoraFluor™ 1]

Product Datasheets

Download Product Datasheets

COA

SDS

Product Specific Notices for TrkA Antibody (MNAC13) [CoraFluor™ 1]

CoraFluor (TM) is a trademark of Bio-Techne Corp. Sold for research purposes only under agreement from Massachusetts General Hospital. US patent 2022/0025254

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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