TrkC Antibody - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-15185

Novus Biologicals, part of Bio-Techne

Key Product Details

Species Reactivity

Validated:

Human, Mouse

Predicted:

Porcine (100%), Primate (100%). Backed by our 100% Guarantee.

Applications

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

1.16 mg/ml

View all TrkC Antibodies »

Product Specifications

Immunogen

A synthetic peptide made to the extracellular domain of the human TrkC protein (within residues 300-400). [UniProt Q16288].

Reactivity Notes

Immunogen has 100% homology to pig and monkey.

Localization

Membrane

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for TrkC Antibody - BSA Free

Immunocytochemistry/ Immunofluorescence: TrkC Antibody - BSA Free [NBP2-15185]

Immunocytochemistry/ Immunofluorescence: TrkC Antibody - BSA Free [NBP2-15185]

Immunocytochemistry/Immunofluorescence: TrkC Antibody [NBP2-15185] - TrkC antibody was tested in neuro2a cells with Dylight 488 (green). Nuclei and alpha-tubulin were counterstained with DAPI (blue) and Dylight 550 (red).
Immunohistochemistry: TrkC Antibody - BSA Free [NBP2-15185]

Immunohistochemistry: TrkC Antibody - BSA Free [NBP2-15185]

Immunohistochemistry: TrkC Antibody [NBP2-15185] - TrkC antibody was tested in mouse brain using DAB with hematoxylin counterstain.

Applications for TrkC Antibody - BSA Free

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

1:1000

Immunohistochemistry

1:200

Immunohistochemistry-Paraffin

1:200
Application Notes
This TrkC antibody is useful for Immunohistochemistry-Paraffin and Immunocytochemistry / Immunofluorescence. In ICC/IF, membrane staining was observed in neuro2a cells. In IHC-P, staining was observed in the membrane of mouse brain. Prior to immunostaining paraffin tissues, antigen retrieval with sodium citrate buffer (pH 6.0) is recommended.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS and 30% Glycerol

Format

BSA Free

Preservative

0.05% Sodium Azide

Concentration

1.16 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: TrkC

Neurotrophic tyrosine kinase receptor type 3 (NTRK3), commonly known as TRKC, is a member of the protein kinase superfamily, the tyrosine (Tyr) protein kinase family, and more specifically, the insulin receptor subfamily. TRKC is a single pass type I membrane protein that phosphorylates itself (via ligand-mediated auto-phosphorylation) and other proteins in the MAPK pathway upon neurotrophin binding. Mutations to the TRKC gene have been correlated with the development of medulloblastomas, secretory breast carcinomas, and other cancers. TRKC has several transcript variants that encode different isoforms (A= 94.4kDa, B= 68.4kDa, C= 92.8kDa, and D= 93.3kDa), and each isoform has unique signaling properties. Cell differentiation that plays a role in the development of proprioceptive neurons originates via signaling through TRKC. The TRKC protein contains two Ig-like C2-type immunoglobulin-like domains, two leucine-rich repeats (LRR), one leucine rich repeat C-terminal (LRRCT) domain, and one protein kinase domain.

Long Name

Neurotrophic Tyrosine Kinase Receptor C

Alternate Names

NTRK3

Entrez Gene IDs

4916 (Human); 18213 (Mouse); 29613 (Rat)

Gene Symbol

NTRK3

UniProt

Q16288, Q6VNS1, Q03351 (Rat)

Additional TrkC Products

Product Documents for TrkC Antibody - BSA Free

Product Datasheets

Certificate of Analysis

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Product Specific Notices for TrkC Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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