tropomyosin-3 Antibody (2E4)

Western Blot: tropomyosin-3 Antibody (2E4) [H00007170-M02] -

Western Blot: tropomyosin-3 Antibody (2E4) [H00007170-M02] - Enrichment of tumor proteins in plasma-derived EVs & classifier performance(A) Differential enrichment of EV proteins was evaluated for proteins with ≥ 3-fold case:control expression & p < 0.05. The average normalized spectral abundance factor (NSAF) for each protein was calculated from respective LC-MS/MS proteomic analyses of adenocarcinoma case plasma-derived EVs (●) black circle; disease free control plasma-derived EVs (○) open circle; & unfractionated plasma from paired cancer, lung disease & control specimens (◊) diamond. (B) Receiver operating characteristic curve analyses of top performing plasma EV protein markers SRGN (red), TPM3 (blue), THBS1 (violet), & HUWE1 (green). The four marker combination (yellow) yielded an AUC of 0.8995. (C) Immunoblot analysis of plasma-derived extracellular vesicles from adenocarcinoma cases & matched controls to demonstrate marker performance in immunoassay. Marker abundance as quantified by densitometry of western blot, lower left; ROC curve analysis of TPM3 performance based on western blot data, lower right. Image collected & cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/29221141), licensed under a CC-BY license. Not internally tested by Novus Biologicals.