tropomyosin-3 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-57472

Novus Biologicals, part of Bio-Techne
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NBP1-57472
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Key Product Details

Species Reactivity

Human

Applications

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

0.5 mg/ml

View all tropomyosin-3 Antibodies »

Product Specifications

Immunogen

Synthetic peptides corresponding to TPM3(tropomyosin 3) The peptide sequence was selected from the middle region of TPM3 (NP_705935). Peptide sequence TEERAELAESRCREMDEQIRLMDQNLKCLSAAEEKYSQKEDKYEEEIKIL. The peptide sequence for this immunogen was taken from within the described region.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

33 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Description

The addition of 50% glycerol is optional for those storing this antibody at -20C and not aliquoting smaller units. However, please note that glycerol may interrupt some downstream antibody applications and should be added with caution.

Scientific Data Images for tropomyosin-3 Antibody

Western Blot: tropomyosin-3 Antibody [NBP1-57472]

Western Blot: tropomyosin-3 Antibody [NBP1-57472]

Western Blot: tropomyosin-3 Antibody [NBP1-57472] - THP-1 cell lysate, concentration 0.2-1 ug/ml.

Applications for tropomyosin-3 Antibody

Application
Recommended Usage

Western Blot

1.0 ug/ml

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, 2% Sucrose

Preservative

0.09% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: tropomyosin-3

TPM3 is a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosins are dimers of coiled-coil proteins that polymerize end-to-end along the major groove in most actin filaments. They provide stability to the filaments and regulate access of other actin-binding proteins. In muscle cells, they regulate muscle contraction by controlling the binding of myosin heads to the actin filament. Mutations in this gene result in autosomal dominant nemaline myopathy, and oncogenes formed by chromosomal translocations involving this locus are associated with cancer.This gene encodes a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosins are dimers of coiled-coil proteins that polymerize end-to-end along the major groove in most actin filaments. They provide stability to the filaments and regulate access of other actin-binding proteins. In muscle cells, they regulate muscle contraction by controlling the binding of myosin heads to the actin filament. Mutations in this gene result in autosomal dominant nemaline myopathy, and oncogenes formed by chromosomal translocations involving this locus are associated with cancer. Multiple transcript variants encoding different isoforms have been found for this gene.

Alternate Names

cytoskeletal tropomyosin TM30, FLJ41118, gamma-tropomyosin, heat-stable cytoskeletal protein 30 kDa, hscp30, hTM5, MGC14582, MGC3261, MGC72094, NEM1, OK/SW-cl.5, TM3, TM30, TM30nm, TM-5, TPMsk3, TRK, tropomyosin 3, tropomyosin alpha-3 chain, tropomyosin gamma, Tropomyosin-3, tropomyosin-5

Entrez Gene IDs

7170 (Human)

Gene Symbol

TPM3

UniProt

P06753 (Human)

Additional tropomyosin-3 Products

Product Documents for tropomyosin-3 Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for tropomyosin-3 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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