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TRPC1 Antibody (JE35-25)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-33060

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-33060

Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat

Applications

Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # JE35-25

Concentration

1 mg/ml

Product Summary for TRPC1 Antibody (JE35-25)

Immunogen

Recombinant protein within Human TRPC1 aa 408-507 / 793. (Uniprot: P48995)

Localization

Membrane.

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

91 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for TRPC1 Antibody (JE35-25)

TRPC1 Antibody (JE35-25)

Western Blot: TRPC1 Antibody (JE35-25) [NBP3-33060]

Western Blot: TRPC1 Antibody (JE35-25) [NBP3-33060] - Western blot analysis of TRPC1 on different lysates with Rabbit anti-TRPC1 antibody (NBP3-33060) at 1/1,000 dilution.

Lane 1: SH-SY5Y cell lysate 15 ug/Lane)
Lane 2: HepG2 cell lysate 15 ug/Lane)
Lane 3: A549 cell lysate 15 ug/Lane)
Lane 4: MCF7 cell lysate 15 ug/Lane)
Lane 5: SK-OV-3 cell lysate 15 ug/Lane)
Lane 6: NIH/3T3 cell lysate 15 ug/Lane)
Lane 7: PC-12 cell lysate 15 ug/Lane)
Lane 8: Human brain tissue lysate (30 ug/Lane)
Lane 9: Mosue brain tissue lysate (30 ug/Lane)
Lane 10: Mosue testis tissue lysate (30 ug/Lane)
Lane 11: Rat testis tissue lysate (30 ug/Lane)

Predicted band size: 91 kDa
Observed band size: 120 kDa

Exposure time: 3 minutes;

4-20% SDS-PAGE gel.

Proteins were transferred to a PVDF membrane and blocked with 5% NFDM/TBST for 1 hour at room temperature. The primary antibody (NBP3-33060) at 1/1,000 dilution was used in 5% NFDM/TBST at room temperature for 2 hours. Goat Anti-Rabbit IgG - HRP Secondary Antibody at 1:100,000 dilution was used for 1 hour at room temperature.

Applications for TRPC1 Antibody (JE35-25)

Application
Recommended Usage

Western Blot

1:1000-1:2000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

1*TBS (pH7.4), 0.05% BSA and 40% Glycerol

Preservative

0.05% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: TRPC1

The TRP1 (TRPC1) gene encodes for a short transient receptor potential channel 1 protein which creates non-selective channels permeable to calcium and other cations. The long isoform is 793 amino acids long at around 91 kDA while the short isoform is 759 amino acids at approximately 87 kDA. These proteins are believed to be operated by a phosphatidylinositol messenger system. The TRP1 gene interacts with MX1, CAV1, ITPR3, HOMER1, and BMPR2 genes in pathways for CREB transcription, intracellular calcium signaling, developmental biology and pancreatic secretion. The TRP1 gene has been studied in various diseases such as kidney disease, breast cancer, neuroblastoma, prostatius, retinitis, basal cell carcinoma, muscular dystrophy, gingivitis, hypoxia, cerebritis, neurodegeneration, pyloric stenosis, and bipolar disorder.

Long Name

Short transient receptor potential channel 1

Alternate Names

TRP-1, TRP1

Gene Symbol

TRPC1

Additional TRPC1 Products

Product Documents for TRPC1 Antibody (JE35-25)

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for TRPC1 Antibody (JE35-25)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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