TRPC1 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-50090

Novus Biologicals, part of Bio-Techne
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NBP2-50090
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Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

This product is unpurified. The exact concentration of antibody is not quantifiable.

View all TRPC1 Antibodies »

Product Specifications

Immunogen

A synthetic peptide from amino acid region 40-90 of human TRPC1 conjugated to blue carrier protein was used as the antigen. The peptide is homologous in rat and mouse.

Specificity

Interacts with TRPC3. Interacts with ITPR3.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for TRPC1 Antibody

Western Blot: TRPC1 Antibody [NBP2-50090]

Western Blot: TRPC1 Antibody [NBP2-50090]

Western Blot: TRPC1 Antibody [NBP2-50090] - WB on mouse brain lysate. Blocking: 1% LFDM for 30 min at RT; primary antibody: dilution 1:2000 incubated at 4C overnight.
Immunohistochemistry-Paraffin: TRPC1 Antibody [NBP2-50090]

Immunohistochemistry-Paraffin: TRPC1 Antibody [NBP2-50090]

Immunohistochemistry-Paraffin: TRPC1 Antibody [NBP2-50090] - IHC-P on paraffin section of mouse cerebellum.
The animal was perfused using Autoperfuser at a pressure of 130 mmHg with 300 ml 4% FA before being processed for paraffin embedding. HIER: Tris-EDTA, pH 9 for 20 min. Blocking: 0.2% LFDM in TBST filtered thru 0.2 um. Detection was done using HRP polymer following manufacturers instructions; DAB chromogen. Primary antibody: dilution 1: 1000, incubated 30 min at RT using Autostainer. Sections were counterstained with Harris Hematoxylin.

Applications for TRPC1 Antibody

Application
Recommended Usage

Immunohistochemistry

1:1000-1:2000

Immunohistochemistry-Paraffin

1:1000-1:2000

Western Blot

1:1000-1:2000

Formulation, Preparation, and Storage

Purification

Unpurified

Reconstitution

Reconstitute in 0.1 ml of sterile water. Centrifuge to remove any insoluble material. Glycerol may be added (1:1) for additional stability.

Formulation

Lyophilized from whole antisera

Preservative

No Preservative

Concentration

This product is unpurified. The exact concentration of antibody is not quantifiable.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: TRPC1

The TRP1 (TRPC1) gene encodes for a short transient receptor potential channel 1 protein which creates non-selective channels permeable to calcium and other cations. The long isoform is 793 amino acids long at around 91 kDA while the short isoform is 759 amino acids at approximately 87 kDA. These proteins are believed to be operated by a phosphatidylinositol messenger system. The TRP1 gene interacts with MX1, CAV1, ITPR3, HOMER1, and BMPR2 genes in pathways for CREB transcription, intracellular calcium signaling, developmental biology and pancreatic secretion. The TRP1 gene has been studied in various diseases such as kidney disease, breast cancer, neuroblastoma, prostatius, retinitis, basal cell carcinoma, muscular dystrophy, gingivitis, hypoxia, cerebritis, neurodegeneration, pyloric stenosis, and bipolar disorder.

Long Name

Short transient receptor potential channel 1

Alternate Names

TRP-1, TRP1

Gene Symbol

TRPC1

UniProt

P48995 (Human), Q61056 (Mouse), Q9QX01 (Rat)

Additional TRPC1 Products

Product Documents for TRPC1 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for TRPC1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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