Trypsin 1/PRSS1 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-46871

Novus Biologicals, part of Bio-Techne
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NBP2-46871
NBP2-46871-25ul
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Mouse (90%), Rat (90%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Trypsin 1/PRSS1 Antibodies »

Product Summary for Trypsin 1/PRSS1 Antibody

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: RIQVRLGEHNIEVLEGNEQFINAAKIIRHP

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Trypsin 1/PRSS1 Antibody

Immunohistochemistry-Paraffin: Trypsin 1/PRSS1 Antibody [NBP2-46871]

Immunohistochemistry-Paraffin: Trypsin 1/PRSS1 Antibody [NBP2-46871]

Immunohistochemistry-Paraffin: Trypsin 1/PRSS1 Antibody [NBP2-46871] - Staining of human pancreas shows strong cytoplasmic positivity in exocrine glandular cells.

Applications for Trypsin 1/PRSS1 Antibody

Application
Recommended Usage

Immunohistochemistry

1:2500 - 1:5000

Immunohistochemistry-Paraffin

1:2500 - 1:5000
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Trypsin 1/PRSS1

Human Trypsin 1, encoded by the PRSS1 gene, is also known as cationic trypsinogen (1). Constituting approximately two-thirds of the total trypsin content in normal pancreatic juice, it is the most abundant trypsin isoform produced by the pancreas. It contains a signal peptide (residues 1-15), a pro region (residues 16-23), and a mature chain (residues 24-247). Trypsin 1 is synthesized in the pancreas and secreted into the duodenum lumen, where it is activated by enterokinase. Its major physiologic function is to digest food and to activate other pro-enzymes (2). Mutations in the PRSS1 gene can cause hereditary pancreatitis (3).

Alternate Names

PRSS1, PTRYI, TRY4, Trygn16, Trypsinogen 1

Entrez Gene IDs

5646 (Human)

Gene Symbol

PRSS3

UniProt

P07477

Additional Trypsin 1/PRSS1 Products

Product Documents for Trypsin 1/PRSS1 Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Trypsin 1/PRSS1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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