Tryptophan Hydroxylase 1/TPH-1 Antibody (TPH1/7662)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-26737

Novus Biologicals, part of Bio-Techne
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Key Product Details

Species Reactivity

Validated:

Human

Applications

Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG2 kappa Clone # TPH1/7662

Concentration

0.2 mg/ml

View all Tryptophan Hydroxylase 1/TPH-1 Antibodies »

Product Summary for Tryptophan Hydroxylase 1/TPH-1 Antibody (TPH1/7662)

Immunogen

Recombinant full-length human Tryptophan Hydroxylase 1/TPH-1 protein

Localization

Cytoplasm, Nucleus

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2 kappa

Description

Antibody with azide - store at 2 to 8C. Antibody without azide - store at -20 to -80C. Non-hazardous. No MSDS required.

Scientific Data Images for Tryptophan Hydroxylase 1/TPH-1 Antibody (TPH1/7662)

Tryptophan Hydroxylase 1/TPH-1 Antibody (TPH1/7662)

Immunohistochemistry-Paraffin: Tryptophan Hydroxylase 1/TPH-1 Antibody (TPH1/7662) [NBP3-26737 ] -

Formalin-fixed, paraffin-embedded human kidney cancer stained with Tryptophan Hydroxylase 1/TPH-1 Antibody (TPH1/7662). HIER: Tris/EDTA, pH9.0, 45min. 2°C: HRP-polymer, 30min. DAB, 5min.

Applications for Tryptophan Hydroxylase 1/TPH-1 Antibody (TPH1/7662)

Application
Recommended Usage

Immunohistochemistry-Paraffin

1-2ug/ml for 30 minutes at RT
Application Notes
Immunohistochemistry-Paraffin 1-2ug/ml for 30 minutes at RT. Optimal dilution for a specific application should be determined.. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95C followed by cooling at RT for 20 minutes
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A or G purified

Formulation

10mM PBS with 0.05% BSA

Preservative

0.05% Sodium Azide

Concentration

0.2 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C.

Background: Tryptophan Hydroxylase 1/TPH-1

Tryptophan hydroxylase (TPH) is the rate-limiting enzyme in the biosynthesis of serotonin (5-HT) and might be related to the pathogenesis of major depression (MD). Two isoforms are known, TPH1 and TPH2. (1). TPH1 is phosphorylated by cAMP-dependent protein kinase A (2). Recently, it has been shown that expression of the TPH1 gene is increased in lungs and pulmonary endothelial cells from patients with idiopathic pulmonary arterial hypertension. Results indicate that TPH1 and peripheral serotonin play an essential role in the development of hypoxia-induced elevations in pulmonary pressures and hypoxia-induced pulmonary vascular remodeling. In addition, the results suggest that, in mice, serotonin has differential effects on the pulmonary vasculature and right ventricular hypertrophy (3).

Alternate Names

TPH-1, TPRH

Gene Symbol

TPH1

Additional Tryptophan Hydroxylase 1/TPH-1 Products

Product Documents for Tryptophan Hydroxylase 1/TPH-1 Antibody (TPH1/7662)

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Certificate of Analysis

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Product Specific Notices for Tryptophan Hydroxylase 1/TPH-1 Antibody (TPH1/7662)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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