Key Product Details

Species Reactivity

Human

Applications

Flow Cytometry, Immunohistochemistry, Immunohistochemistry-Frozen, Immunohistochemistry-Paraffin, Immunoprecipitation, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG2A Clone # 4C1

Concentration

1.0 mg/ml

View all TSHR Antibodies »

Product Specifications

Immunogen

External domain of human TSH receptor

Specificity

Recognizes the human thyroid stimulating hormone (TSH) receptor (otherwise known as the thyrotropin receptor) binding to an extracellular domain.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2A

Scientific Data Images for TSHR Antibody (4C1)

Immunohistochemistry-Paraffin: TSHR Antibody (4C1) - BSA Free [NB100-65797]

Immunohistochemistry-Paraffin: TSHR Antibody (4C1) - BSA Free [NB100-65797]

Immunohistochemistry-Paraffin: TSH R Antibody (4C1) [NB100-65797] - Human thyroid.

Applications for TSHR Antibody (4C1)

Application
Recommended Usage

Flow Cytometry

1:100-1:1000

Immunohistochemistry

1:10-1:500

Immunohistochemistry-Frozen

1:10-1:500

Immunohistochemistry-Paraffin

1:1000-1:2000
Application Notes
This product does not require protein digestion pre-treatment of paraffin sections. This product does not require antigen retrieval using heat treatment prior to staining of paraffin sections.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

PBS

Preservative

0.09% Sodium Azide

Concentration

1.0 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: TSHR

Thyroid stimulating hormone, also known as thyrotropin, is secreted from cells in the anterior pituitary called thyrotrophs, finds its receptors on epithelial cells in the thyroid gland, and stimulates that gland to synthesize and release thyroid hormones. TSH is a glycoprotein hormone composed of two subunits which are non covalently bound to one another. The alpha subunit of TSH is also present in two other pituitary glycoprotein hormones, follicle stimulating hormone and luteinizing hormone, and, in primates, in the placental hormone chorionic gonadotropin. Each of these hormones also has a unique beta subunit, which provides receptor specificity. In other words, TSH is composed of alpha subunit bound to the TSH beta subunit, and TSH associates only with its own receptor. Free alpha and beta subunits have essentially no biological activity.

Long Name

Thyroid Stimulating Hormone Receptor

Alternate Names

CHNG1, LGR3, TSH R

Entrez Gene IDs

7253 (Human)

Gene Symbol

TSHR

UniProt

P16473

Additional TSHR Products

Product Documents for TSHR Antibody (4C1)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for TSHR Antibody (4C1)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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