TWEAK R/TNFRSF12 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB100-56636

Novus Biologicals, part of Bio-Techne
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NB100-56636
NB100-56636SS
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Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat

Cited:

Rat

Applications

Validated:

Western Blot

Cited:

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

0.5 mg/ml

View all TWEAK R/TNFRSF12 Antibodies »

Product Specifications

Immunogen

This antibody was developed against a synthetic peptide containing amino acids 106-118 (CRREKFTTPIEETG) of human TweakR.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for TWEAK R/TNFRSF12 Antibody

Western Blot: TWEAK R/TNFRSF12 Antibody [NB100-56636]

Western Blot: TWEAK R/TNFRSF12 Antibody [NB100-56636]

Western Blot: TWEAK R/TNFRSF12 Antibody [NB100-56636] - Analysis of TweakR in A) human liver lysate , B) mouse liver tissue lysate , and C) rat liver lysate using this antibody at 1:500.
Western Blot: TWEAK R/TNFRSF12 Antibody [NB100-56636]

Western Blot: TWEAK R/TNFRSF12 Antibody [NB100-56636]

Western Blot: TWEAK R/TNFRSF12 Antibody [NB100-56636] - Analysis of TweakR in 293 cells. Untransfected (lane 1) or transfectd with human TweakR (lane 2). Photograph courtesy of Dr. Taly Spivakk, The MD Anderson Cancer Center, Houston, TX.

Applications for TWEAK R/TNFRSF12 Antibody

Application
Recommended Usage

Western Blot

2-4 ug/ml

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

PBS containing 0.05% BSA

Preservative

0.05% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: TWEAK R/TNFRSF12

TWEAK is a member of the TNF family and was first described as a weak inducer of apoptosis in demonstrate that this relatively small molecule is a fully transformed cell lines (1, 2). Recently, a receptor for TWEAK was isolated by expression cloning from a HUVEC cell cDNA library (3). TweakR is a small protein belonging to TNF receptor super family. TweakR is capable of intiating a proliferative signal by biding to TRAF1, 2, and 3. TweakR mRNA is upregulated during tissue regeneration in aorta and liver. It may also play a role in vascular cell migration and angiogenesis.

Long Name

TNF-like and Weak Inducer of Apoptosis Receptor

Alternate Names

CD266, Fn14, TNFRSF12, TNFRSF12A, TWEAKR

Entrez Gene IDs

51330 (Human); 27279 (Mouse); 302965 (Rat)

Gene Symbol

TNFRSF12A

Additional TWEAK R/TNFRSF12 Products

Product Documents for TWEAK R/TNFRSF12 Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for TWEAK R/TNFRSF12 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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