TWEAK R/TNFRSF12 Antibody - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-34499

Novus Biologicals, part of Bio-Techne

Key Product Details

Species Reactivity

Human

Applications

ELISA, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

1 mg/ml

View all TWEAK R/TNFRSF12 Antibodies »

Product Specifications

Immunogen

Antibody was raised against a human IgG1 Fc-tagged Fn14 protein.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for TWEAK R/TNFRSF12 Antibody - BSA Free

Western Blot: TWEAK R/TNFRSF12 AntibodyBSA Free [NBP2-34499]

Western Blot: TWEAK R/TNFRSF12 AntibodyBSA Free [NBP2-34499]

Western Blot: TWEAK R/TNFRSF12 Antibody [NBP2-34499] - Analysis of Fn14 in HepG2 cells with Fn14 antibody at (A) 2 and (B) 4 ug/mL.
Immunocytochemistry/ Immunofluorescence: TWEAK R/TNFRSF12 Antibody - BSA Free [NBP2-34499]

Immunocytochemistry/ Immunofluorescence: TWEAK R/TNFRSF12 Antibody - BSA Free [NBP2-34499]

Immunocytochemistry/Immunofluorescence: TWEAK R/TNFRSF12 Antibody [NBP2-34499] - Fn14 in Human Liver cells with Fn14 antibody at 20 ug/mL.
Immunohistochemistry: TWEAK R/TNFRSF12 Antibody - BSA Free [NBP2-34499]

Immunohistochemistry: TWEAK R/TNFRSF12 Antibody - BSA Free [NBP2-34499]

Immunohistochemistry: TWEAK R/TNFRSF12 Antibody [NBP2-34499] - Fn14 in human liver tissue with Fn14 antibody at 2.5 ug/mL.
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Applications for TWEAK R/TNFRSF12 Antibody - BSA Free

Application
Recommended Usage

ELISA

1:100-1:2000

Immunohistochemistry

1:10-1:500

Immunohistochemistry-Paraffin

1:10-1:500

Western Blot

1:100-1:2000

Formulation, Preparation, and Storage

Purification

Peptide affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: TWEAK R/TNFRSF12

TWEAK is a TNF family member produced by IFN-gamma-stimulated monocytes and induces multiple cell death pathways including caspase-dependent apoptosis and cathepsin B-dependent necrosis. These pathways are mediated by the binding of TWEAK by fibroblast growth factor 14 (Fn14), a member of the TNF receptor superfamily. Yeast two-hybrid experiments have shown that FN14 will bind to the TNFR-associated factors TRAF1, TRAF2, TRAF3, and TRAF5, suggesting that the signaling pathway induced by TWEAK may be mediated by one or more of these adaptor molecules. Fn14 is induced during liver regeneration and is highly expressed in hepatocellular carcinomas. In addition, TWEAK induces liver progenitor cell proliferation, suggesting Fn14 may play a role in hepatocyte growth control and liver neoplasia.

Long Name

TNF-like and Weak Inducer of Apoptosis Receptor

Alternate Names

CD266, Fn14, TNFRSF12, TNFRSF12A, TWEAKR

Gene Symbol

TNFRSF12A

UniProt

NP_057723

Additional TWEAK R/TNFRSF12 Products

Product Documents for TWEAK R/TNFRSF12 Antibody - BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for TWEAK R/TNFRSF12 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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