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TWEAK/TNFSF12 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-46811

Novus Biologicals, part of Bio-Techne
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NBP2-46811
NBP2-46811-25ul

Key Product Details

Species Reactivity

Validated:

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Product Summary for TWEAK/TNFSF12 Antibody

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: QEPAQEELVAEEDQDPSELNPQTEESQDPAPFLNRLVRPRRSAPKGRKTRARRAIAAHYEVHPRPGQDGAQAGVDGTVSGWEEARINSSSPLRYNRQIGEFIVTRAGLYYLYC

Reactivity Notes

Immunogen displays the following percentage of sequence identity for non-tested species: Mouse (84%), Rat (81%)

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for TWEAK/TNFSF12 Antibody

TWEAK/TNFSF12 Antibody

Immunohistochemistry: TWEAK/TNFSF12 Antibody [NBP2-46811] -

Immunohistochemistry: TWEAK/TNFSF12 Antibody [NBP2-46811] - Staining of human skin shows strong cytoplasmic positivity in squamous epithelial cells.
TWEAK/TNFSF12 Antibody

Immunohistochemistry: TWEAK/TNFSF12 Antibody [NBP2-46811] -

Immunohistochemistry: TWEAK/TNFSF12 Antibody [NBP2-46811] - Staining of human skeletal muscle shows strong cytoplasmic positivity in myocytes.
TWEAK/TNFSF12 Antibody

Immunohistochemistry: TWEAK/TNFSF12 Antibody [NBP2-46811] -

Immunohistochemistry: TWEAK/TNFSF12 Antibody [NBP2-46811] -Staining of human rectum shows strong cytoplasmic positivity in glandular cells.

Applications for TWEAK/TNFSF12 Antibody

Application
Recommended Usage

Immunohistochemistry

1:50 - 1:200

Immunohistochemistry-Paraffin

1:50 - 1:200
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: TWEAK/TNFSF12

CD266 is a 14 kD transmembrane protein known as TWEAK receptor (TWEAK-R) or fibroblast growth factor inducible 14 (Fn14). It is member 12A of the tumor necrosis factor receptor superfamily (TNFRSF12A) expressed at low levels in a variety of tissues, such as heart, placenta, lung, muscle, and pancreas. TWEAK-R binds TWEAK (CD255) and interacts with the cytoplasmic proteins TRAF1, 2, and 3. The engagement of Fn14 can induce cell death and may play a role in inflammation, hepatocyte growth, and liver neoplasia. ITEM-4 antibody reacts with both mouse and human Fn14. It is useful for flow cytometric analysis.

Long Name

TNF-like and Weak Inducer of Apoptosis

Alternate Names

TNFSF12

Entrez Gene IDs

8742 (Human)

Gene Symbol

TNFSF12

UniProt

Additional TWEAK/TNFSF12 Products

Product Documents for TWEAK/TNFSF12 Antibody

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for TWEAK/TNFSF12 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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