Tyrosinase Antibody (2A2-F4)

Novus Biologicals, part of Bio-Techne | Catalog # H00007299-M01

Novus Biologicals, part of Bio-Techne
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Key Product Details

Species Reactivity

Human

Applications

ELISA, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 kappa Clone # 2A2-F4

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Tyrosinase Antibodies »

Product Specifications

Immunogen

TYR (AAH27179.1, 1 a.a. ~ 377 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. MLLAVLYCLLWSFQTSAGHFPRACVSSKNLMEKECCPPWSGDRSPCGQLSGRGSCQNILLSNAPLGPQFPFTGVDDRESWPSVFYNRTCQCSGNFMGFNCGNCKFGFWGPNCTERRLLVRRNIFDLSAPEKDKFFAYLTLAKHTISSDYVIPIGTYGQMKNGSTPMFNDINIYDLFVWMHYYVSMDALLGGSEIWRDIDFAHEAPAFLPWHRLFLLRWEQEIQKLTGDENFTIPYWDWRDAEKCDICTDEYMGGQHPTNPNLLSPASFFSSWQIVCSRLEEYNSHQPLCNGTPEGPLRRNPGNHDKSRTPRLPSSADVEFCLSLTQYESGSMDKAANFSFRNTLEEMGFLHVGWAGLKLLTSRDPPPWPPKMLGLQA

Localization

Melanosomal membrane; single pass type I membrane protein.

Specificity

TYR - tyrosinase (oculocutaneous albinism IA)

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1 kappa

Description

Quality control test: Antibody Reactive Against Recombinant Protein.

Scientific Data Images for Tyrosinase Antibody (2A2-F4)

Western Blot: Tyrosinase Antibody (2A2-F4) [H00007299-M01]

Western Blot: Tyrosinase Antibody (2A2-F4) [H00007299-M01]

Western Blot: Tyrosinase Antibody (2A2-F4) [H00007299-M01] - TYR monoclonal antibody (M01), clone 2A2-F4 Analysis of TYR expression in A-431.
Immunocytochemistry/ Immunofluorescence: Tyrosinase Antibody (2A2-F4) [H00007299-M01]

Immunocytochemistry/ Immunofluorescence: Tyrosinase Antibody (2A2-F4) [H00007299-M01]

Immunocytochemistry/Immunofluorescence: Tyrosinase Antibody (2A2-F4) [H00007299-M01] - Analysis of monoclonal antibody to TYR on Jurkat cell . Antibody concentration 10 ug/ml.
Immunohistochemistry-Paraffin: Tyrosinase Antibody (2A2-F4) [H00007299-M01]

Immunohistochemistry-Paraffin: Tyrosinase Antibody (2A2-F4) [H00007299-M01]

Immunohistochemistry-Paraffin: Tyrosinase Antibody (2A2-F4) [H00007299-M01] - Analysis of monoclonal antibody to TYR on formalin-fixed paraffin-embedded human liver tissue. Antibody concentration 3 ug/ml.

Applications for Tyrosinase Antibody (2A2-F4)

Application
Recommended Usage

ELISA

Optimal dilutions of this antibody should be experimentally determined.

Immunocytochemistry/ Immunofluorescence

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry-Paraffin

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Antibody reactivity against cell lysate and recombinant protein for WB. It has also been used for IHC-P and ELISA.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

IgG purified

Formulation

In 1x PBS, pH 7.4

Preservative

No Preservative

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Background: Tyrosinase

Tyrosinase is a copper containing metalloglycoprotein that catalyzes several steps in the melanin pigment biosynthetic pathway. It is thought to catalyze the rate-limiting conversions of tyrosine to DOPA, DOPA to DOPA-quinone and possibly 5,6-dihydroxyindole to indole-5,6 quinone. A mutant allele of TYR is a common cause of autosomal recessive ocular albinism, also known as tyrosinase negative oculocutaneous albinism. This is an autosomal recessive disorder characterized by absence of pigment in hair, skin and eyes.

Alternate Names

CMM8, EC 1.14.18.1, LB24-AB, Monophenol monooxygenase, OCA1A, OCAIA, SHEP3, SK29-AB, Tumor rejection antigen AB, tyrosinase, tyrosinase (oculocutaneous albinism IA)

Entrez Gene IDs

7299 (Human)

Gene Symbol

TYR

OMIM

103 (Human)

UniProt

AAH27179 (Human)

Additional Tyrosinase Products

Product Documents for Tyrosinase Antibody (2A2-F4)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for Tyrosinase Antibody (2A2-F4)

This product is produced by and distributed for Abnova, a company based in Taiwan.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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