u-Plasminogen Activator/Urokinase Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-20819

Novus Biologicals, part of Bio-Techne
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NBP2-20819
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Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all u-Plasminogen Activator (uPA)/Urokinase Antibodies »

Product Specifications

Immunogen

Recombinant protein encompassing a sequence within the center region of human u-Plasminogen Activator/Urokinase. The exact sequence is proprietary.

Reactivity Notes

Immunogen displays the following percentage of sequence identity for non-tested species: Canine (81%), Porcine (82%), Rabbit (85%), Sheep (81%).

Localization

Secreted

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

49 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for u-Plasminogen Activator/Urokinase Antibody

Western Blot: u-Plasminogen Activator/Urokinase Antibody [NBP2-20819]

Western Blot: u-Plasminogen Activator/Urokinase Antibody [NBP2-20819]

Western Blot: u-Plasminogen Activator/Urokinase Antibody [NBP2-20819] - Sample (30 ug of whole cell lysate) A: IMR32 10% SDS PAGE diluted at 1:2000
Immunohistochemistry-Paraffin: u-Plasminogen Activator/Urokinase Antibody [NBP2-20819]

Immunohistochemistry-Paraffin: u-Plasminogen Activator/Urokinase Antibody [NBP2-20819]

Immunohistochemistry-Paraffin: u-Plasminogen Activator/Urokinase Antibody [NBP2-20819] - Analysis of paraffin-embedded human colon carcinoma, using Urokinase antibody at 1:250 dilution.

Applications for u-Plasminogen Activator/Urokinase Antibody

Application
Recommended Usage

Immunohistochemistry

1:100-1:1000

Immunohistochemistry-Paraffin

1:100-1:1000

Western Blot

1:500-1:3000

Formulation, Preparation, and Storage

Purification

Antigen Affinity-purified

Formulation

0.1M Tris (pH 7), 0.1M Glycine, 20% Glycerol

Preservative

0.01% Thimerosal

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Background: u-Plasminogen Activator (uPA)/Urokinase

This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer's disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Long Name

Urokinase-type Plasminogen Activator

Alternate Names

PLAU, uPA, uPlasminogen Activator, Urokinase

Gene Symbol

PLAU

UniProt

P00749

Additional u-Plasminogen Activator (uPA)/Urokinase Products

Product Documents for u-Plasminogen Activator/Urokinase Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for u-Plasminogen Activator/Urokinase Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause reproductive toxicity with developmental effects.  For more information go to www.P65Warnings.ca.gov.

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