UBR4 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-28724

Novus Biologicals, part of Bio-Techne
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NBP1-28724
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Mouse (100%), Rat (100%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Immunoprecipitation (Negative), Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

0.2 mg/ml

View all UBR4 Antibodies »

Product Specifications

Immunogen

The immunogen recognized by this antibody maps to a region between residue 5133 and 5183 of human retinoblastoma-associated factor 600 using the numbering given in entry NP_065816.1 (GeneID 23352).

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for UBR4 Antibody

Western Blot: UBR4 Antibody [NBP1-28724]

Western Blot: UBR4 Antibody [NBP1-28724]

Western Blot: UBR4 Antibody [NBP1-28724] - Whole cell lysate (5, 15 and 50 ug) from HeLa cells. Antibody used for WB at 0.04 ug/ml.
Immunohistochemistry: UBR4 Antibody [NBP1-28724]

Immunohistochemistry: UBR4 Antibody [NBP1-28724]

Immunohistochemistry: UBR4 Antibody [NBP1-28724] - Sample: FFPE section of human prostate carcinoma. Antibody: Affinity purified rabbit anti- p600 used at a dilution of 1:200 (1ug/ml). Detection: DAB

Applications for UBR4 Antibody

Application
Recommended Usage

Immunohistochemistry

1:100- 1:500

Immunohistochemistry-Paraffin

1:100- 1:500

Western Blot

1:2000-1:10000
Application Notes
Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

TBS and 0.1% BSA

Preservative

0.09% Sodium Azide

Concentration

0.2 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C. Do not freeze.

Background: UBR4

p600 is an E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. It recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Together with clathrin, p600 forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization. Additionally p600 regulates integrin-mediated signaling and may play a role in activation of FAK in response to cell-matrix interactions.

Alternate Names

600 kDa retinoblastoma protein-associated factor, EC 6.3.2, EC 6.3.2.-, KIAA0462E3 ubiquitin-protein ligase UBR4, KIAA1307zinc finger, UBR1 type 1, N-recognin-4, p600, RBAF600FLJ41863, Retinoblastoma-associated factor of 600 kDa, ubiquitin protein ligase E3 component n-recognin 4, Zinc finger UBR1-type protein 1, ZUBR1retinoblastoma-associated factor 600-like protein

Entrez Gene IDs

23352 (Human)

Gene Symbol

UBR4

UniProt

NP_065816.1 (Human)

Additional UBR4 Products

Product Documents for UBR4 Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for UBR4 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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