Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCHL1) is a soluble cytoplasmic protein found in neurons and in cells of the diffuse neuroendocrine system, and their respective tumors. Therefore, UCH-L1 has been widely used as a peripheral nerve fiber marker. UCHL-1 functions as a tissue-specific ubiquitin carboxyl terminal hydrolase isoenzyme involved in the processing of both ubiquitin precursors and ubiquitinated proteins.

UCH L1 is down-regulated in brains from Parkinson disease and Alzheimer disease patients, and certian site specific mutations in the UCHL1 gene can either increase or decrese the risk of Parkinson's and/or Alzheimer's neurodegenerative diseases.

Human UCHL 1 and the closely related UCHL3 protein have one of the most complicated knot structures ever discovered, with five knot crossings. This knot structure is expected to help the protein resist degradation in the proteasome.

Long Name

Ubiquitin C-terminal Hydrolase L1

Alternate Names

PARK5, PGP9.5, UCHL1

Gene Symbol

UCHL1

Additional UCH-L1/PGP9.5 Products

Product Documents for UCH-L1/PGP9.5 Antibody (972106) [HRP]

Product Datasheets

Download Product Datasheets

COA

SDS

Download SDS

Product Specific Notices for UCH-L1/PGP9.5 Antibody (972106) [HRP]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Citations
Reviews

UCH-L1/PGP9.5 Antibody (972106) [HRP]

Novus Biologicals, part of Bio-Techne | Catalog # MAB60071H

Key Product Details

Species Reactivity

Applications

Label

Antibody Source

Concentration

View all UCH-L1/PGP9.5 Antibodies »

Product Specifications

Immunogen

Clonality

Host

Isotype

Applications for UCH-L1/PGP9.5 Antibody (972106) [HRP]

Immunohistochemistry

Immunohistochemistry-Paraffin

Simple Western

Western Blot

Formulation, Preparation, and Storage

Purification

Formulation

Preservative

Concentration

Shipping

Stability & Storage

Background: UCH-L1/PGP9.5