UEV2 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB100-56360

Novus Biologicals, part of Bio-Techne
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NB100-56360
NB100-56360SS
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Key Product Details

Species Reactivity

Validated:

Human

Applications

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

0.5 mg/ml

View all UBE2V2 Antibodies »

Product Summary for UEV2 Antibody

Immunogen

This antibody was generated by immunizing rabbit with a mixture of synthetic peptides containing amino acids 12-28 of human UBE2V2.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for UEV2 Antibody

Western Blot: UEV2 Antibody [NB100-56360]

Western Blot: UEV2 Antibody [NB100-56360]

Western Blot: UEV2 Antibody [NB100-56360] - Detection of UBE2V2 in HL-60 cell lysate with anti-UBE2V2 pcAb this antibody at 2ug/ml.

Applications for UEV2 Antibody

Application
Recommended Usage

Western Blot

2 ug/ml
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

PBS containing 0.2% gelatin

Preservative

0.05% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: UBE2V2

The differentiation and activation of monocytes (MO) and monocytic cells is modulated by 1alpha,25-dihydroxyvitamin D3 (Vitamin D3). Recently, using mRNA Differential Display technology, Fritsche J, et al have identified a gene which is induced in freshly isolated human blood MO that are cultured for 4 hours with Vitamin D3. This cDNA encodes a putative 16.5 kD protein. The product of this gene has structural homology with yeast MMS2p and human CROC-1), which defines a structurally and functionally conserved Ubc-like protein family. This protein was called Ubiquitin E2 variant (UBE2V2) or MMS2 (methyl methanesulfonate sensitive 2). The yeast UEV protein, Mms2, is required together with Ubc13 for RAD6/RAD18-dependent postreplicative DNA repair in yeast. These proteins also play a central role in the assembly of K63-linked polyubiquitin chains UEV/Ubc complexes have been implicated in the assembly of Lys63-linked polyubiquitin chains that act as a novel signal in postreplicative DNA repair and IkBa kinase activation. Recent crystal structure analysis provides direct evidence that the Mms2/Ubc13 heterodimer is necessary for DNA repair.

Long Name

Ubiquitin-conjugating Enzyme E2V 2

Alternate Names

DDVit-1, EDAF-1, EDPF1, MMS2, Uev2

Entrez Gene IDs

7336 (Human)

Gene Symbol

UBE2V2

UniProt

NP_003341 (Human)

Additional UBE2V2 Products

Product Documents for UEV2 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for UEV2 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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