ULBP-2 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # H00080328-B01P

Novus Biologicals, part of Bio-Techne
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Key Product Details

Species Reactivity

Validated:

Human

Cited:

Human

Applications

Validated:

Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Western Blot

Cited:

Immunocytochemistry/ Immunofluorescence

Label

Unconjugated

Antibody Source

Polyclonal Mouse IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all ULBP-2 Antibodies »

Product Specifications

Immunogen

ULBP2 (AAH34689, 1 a.a. - 246 a.a.) full-length human protein. MEAAAATKILLCLPLLLLLSGWSRAGRADPHSLCYDITVIPKFRPGPRWCAVQGQVDEKTFLHYDCGNKTVTPVSPLGKKLNVTTAWKAQNPVLREVVDILTEQLRDIQLENYTPKEPLTLQARMSCEQKAEGHSSGSWQFSFDGQIFLLFDSEKRMWTTVHPGARKMKEKWENDKVVAMSFHYFSMGDCIGWLEDFLMGMDSTLEPSAGAPLAMSSGTTQLRATATTLILCCLLIILPCFILPGI

Specificity

ULBP2 - UL16 binding protein 2,

Clonality

Polyclonal

Host

Mouse

Isotype

IgG

Scientific Data Images for ULBP-2 Antibody

Western Blot: ULBP-2 Antibody [H00080328-B01P]

Western Blot: ULBP-2 Antibody [H00080328-B01P]

Western Blot: ULBP-2 Antibody [H00080328-B01P] - Analysis of ULBP2 expression in human ovarian cancer.
Flow Cytometry: ULBP-2 Antibody [H00080328-B01P]

Flow Cytometry: ULBP-2 Antibody [H00080328-B01P]

Flow Cytometry: ULBP-2 Antibody [H00080328-B01P] - Analysis of negative control 293 cells (Black) and ULBP2 expressing 293 cells (Green) using ULBP2 purified mouse polyclonal antibody.
Western Blot: ULBP-2 Antibody [H00080328-B01P]

Western Blot: ULBP-2 Antibody [H00080328-B01P]

Western Blot: ULBP-2 Antibody [H00080328-B01P] - Analysis of ULBP2 expression in transfected 293T cell line by ULBP2 polyclonal antibody. Lane 1: ULBP2 transfected lysate(27.17 KDa). Lane 2: Non-transfected lysate.

Applications for ULBP-2 Antibody

Application
Recommended Usage

Western Blot

1:500
Application Notes
Antibody reactive against transfected lysate and tissue lysate for Western Blot. Has also been used for ELISA and FACS analysis. Use in Immunocytochemistry/immunofluorescence reported in scientific literature (PMID 26046815)

Formulation, Preparation, and Storage

Purification

IgG purified

Formulation

PBS (pH 7.4)

Preservative

No Preservative

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Background: ULBP-2

Ligand for the NKG2D receptor, together with at least ULBP1 and ULBP3. ULBPs activate multiple signalingpathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands toNKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transductionpathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked theinteraction with the NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system.UL16 also causes ULBP2 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface

Long Name

UL16 Binding Protein-2

Alternate Names

ALCAN-alpha, N2DL2, NKG2DL2, RAET1H, ULBP2

Entrez Gene IDs

80328 (Human)

Gene Symbol

ULBP2

UniProt

AAH34689 (Human)

Additional ULBP-2 Products

Product Documents for ULBP-2 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for ULBP-2 Antibody

This product is produced by and distributed for Abnova, a company based in Taiwan.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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