ULBP-2 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-25217

Novus Biologicals, part of Bio-Techne
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NBP3-25217
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Key Product Details

Species Reactivity

Human

Applications

Immunocytochemistry/ Immunofluorescence, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all ULBP-2 Antibodies »

Product Specifications

Immunogen

This antibody has been engineered to specifically recognize the recombinant protein ULBP-2 using the following amino acid sequence: AWKAQNPVLREVVDILTEQLRDIQLENY

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for ULBP-2 Antibody

ULBP-2 Antibody Immunocytochemistry/Immunofluorescence: ULBP-2 Antibody [NBP3-25217]

Immunocytochemistry/Immunofluorescence: ULBP-2 Antibody [NBP3-25217]

Staining of human cell line SiHa shows localization to vesicles.
ULBP-2 Antibody Western Blot: ULBP-2 Antibody [NBP3-25217]

Western Blot: ULBP-2 Antibody [NBP3-25217]

Analysis in human cell line RT-4 and human cell line U-251 MG.

Applications for ULBP-2 Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

0.25-2 µg/ml

Western Blot

0.04-0.4 µg/ml
Application Notes
For ICC/IF, we recommend using a combination of PFA and Triton X-100. This will give you the optimal results for your experiments.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, pH 7.2, 40% glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: ULBP-2

Ligand for the NKG2D receptor, together with at least ULBP1 and ULBP3. ULBPs activate multiple signalingpathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands toNKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transductionpathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked theinteraction with the NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system.UL16 also causes ULBP2 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface

Long Name

UL16 Binding Protein-2

Alternate Names

ALCAN-alpha, N2DL2, NKG2DL2, RAET1H, ULBP2

Gene Symbol

ULBP2

Additional ULBP-2 Products

Product Documents for ULBP-2 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for ULBP-2 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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