Uromodulin Antibody (10.32) - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-50321

Novus Biologicals, part of Bio-Techne
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NBP1-50321
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Key Product Details

Species Reactivity

Validated:

Human, Canine

Cited:

Human

Applications

Validated:

Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Frozen, Immunohistochemistry-Paraffin

Cited:

Hydrolysis Assay

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG2B Clone # 10.32

Format

BSA Free

Concentration

1 mg/ml

View all Uromodulin Antibodies »

Product Specifications

Immunogen

Human Uromodulin protein.

Specificity

Anti-human Uromodulin is a monoclonal antibody which reacts with an epitope of the urinary mucoprotein. Uromodulin is a glycoprotein of approximately 80 kDa containing up to 25% carbohydrate by weight.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2B

Scientific Data Images for Uromodulin Antibody (10.32) - BSA Free

Immunohistochemistry-Frozen: Uromodulin Antibody (10.32) - BSA Free [NBP1-50321]

Immunohistochemistry-Frozen: Uromodulin Antibody (10.32) - BSA Free [NBP1-50321]

Immunohistochemistry-Frozen: Uromodulin Antibody (10.32) [NBP1-50321] - Human kidney tissue section stained with Uromodulin antibody. IHC-Fr image submitted by a verified customer review.
Immunohistochemistry-Paraffin: Uromodulin Antibody (10.32) - BSA Free [NBP1-50321]

Immunohistochemistry-Paraffin: Uromodulin Antibody (10.32) - BSA Free [NBP1-50321]

Immunohistochemistry-Paraffin: Uromodulin Antibody (10.32) [NBP1-50321] - Analysis of anti-UMOD / Uromodulin antibody with human kidney at concentration 20 ug/mL.
Immunohistochemistry-Paraffin: Uromodulin Antibody (10.32) - BSA Free [NBP1-50321]

Immunohistochemistry-Paraffin: Uromodulin Antibody (10.32) - BSA Free [NBP1-50321]

Immunohistochemistry-Paraffin: Uromodulin Antibody (10.32) [NBP1-50321] - Human kidney tissue, staining in kidney tubules. Heat mediated antigen retrieval was performed by heating in citrate buffer (pH 6) at 95C for 20 minutes. IHC-P image submitted by a verified customer review.

Applications for Uromodulin Antibody (10.32) - BSA Free

Application
Recommended Usage

Immunofluorescence

1:10 - 1:500

Immunohistochemistry

5 - 10 ug/mL

Immunohistochemistry-Frozen

1:10 - 1:500

Immunohistochemistry-Paraffin

5 - 10 ug/mL
Application Notes
This Uromodulin antibody is validated for IHC-P from a verified customer review..

Reviewed Applications

Read 2 reviews rated 5 using NBP1-50321 in the following applications:

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Uromodulin

This gene encodes uromodulin, the most abundant protein in normal urine. Its excretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. Uromodulin may act as a constitutive inhibitor of calcium crystallization in renal fluids. Excretion of uromodulin in urine may provide defense against urinary tract infections caused by uropathogenic bacteria. Defects in this gene are associated with the autosomal dominant renal disorders medullary cystic kidney disease-2 (MCKD2) and familial juvenile hyperuricemic nephropathy (FJHN). These disorders are characterized by juvenile onset of hyperuricemia, gout, and progressive renal failure. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same isoform. [provided by RefSeq]

Alternate Names

ADMCKD2, FJHN, HNFJ, MCKD2, THGP, THP, UMOD, Uromucoid

Entrez Gene IDs

7369 (Human)

Gene Symbol

UMOD

UniProt

P07911

Additional Uromodulin Products

Product Documents for Uromodulin Antibody (10.32) - BSA Free

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Uromodulin Antibody (10.32) - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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