Uromodulin Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-33730

Novus Biologicals, part of Bio-Techne
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NBP2-33730
NBP2-33730-25ul
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Key Product Details

Validated by

Orthogonal Validation, Independent Antibodies

Species Reactivity

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Uromodulin Antibodies »

Product Specifications

Immunogen

This antibody was developed against a recombinant protein corresponding to amino acids: SLGFDKVFMYLSDSRCSGFNDRDNRDWVSVVTPARDGPCGTVLTRNETHATYSNTLYLADEIIIRDLNIKINFACSYP

Reactivity Notes

Immunogen displays the following percentage of sequence identity for non-tested species: Rat (81%)

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Uromodulin Antibody

Immunohistochemistry-Paraffin: Uromodulin Antibody [NBP2-33730]

Immunohistochemistry-Paraffin: Uromodulin Antibody [NBP2-33730]

Immunohistochemistry-Paraffin: Uromodulin Antibody [NBP2-33730] - Staining in human kidney and cerebral cortex tissues using NBP2-33730 antibody. Corresponding UMOD RNA-seq data are presented for the same tissues.
Immunohistochemistry-Paraffin: Uromodulin Antibody [NBP2-33730]

Immunohistochemistry-Paraffin: Uromodulin Antibody [NBP2-33730]

Immunohistochemistry-Paraffin: Uromodulin Antibody [NBP2-33730] - Staining of human cerebral cortex shows no positivity in neurons as expected.
Immunohistochemistry-Paraffin: Uromodulin Antibody [NBP2-33730]

Immunohistochemistry-Paraffin: Uromodulin Antibody [NBP2-33730]

Immunohistochemistry-Paraffin: Uromodulin Antibody [NBP2-33730] - Staining of human cerebral cortex, kidney, placenta and testis using Anti-UMOD antibody NBP2-33730 (A) shows similar protein distribution across tissues to independent antibody NBP2-33393 (B).
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Applications for Uromodulin Antibody

Application
Recommended Usage

Immunohistochemistry

1:50 - 1:200

Immunohistochemistry-Paraffin

1:50 - 1:200
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Uromodulin

Uromodulin encodes uromodulin, the most abundant protein in normal urine. Its excretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. Uromodulin may act as a constitutive inhibitor of calcium crystallization in renal fluids. Excretion of uromodulin in urine may provide defense against urinary tract infections caused by uropathogenic bacteria. Defects in this gene are associated with the autosomal dominant renal disorders medullary cystic kidney disease-2 (MCKD2) and familial juvenile hyperuricemic nephropathy (FJHN). These disorders are characterized by juvenile onset of hyperuricemia, gout, and progressive renal failure. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same isoform. [provided by RefSeq]

Alternate Names

ADMCKD2, FJHN, HNFJ, MCKD2, THGP, THP, UMOD, Uromucoid

Gene Symbol

UMOD

UniProt

P07911

Additional Uromodulin Products

Product Documents for Uromodulin Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Uromodulin Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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