USP7 Antibody (S02-6B8)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-19800

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-19800-100ul
NBP3-19800-50ul
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Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # S02-6B8

Concentration

0.3 mg/ml

View all USP7 Antibodies »

Product Specifications

Immunogen

A synthetic peptide of human USP7 (Uniprot # Q93009)

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

128 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for USP7 Antibody (S02-6B8)

Western Blot: USP7 Antibody (S02-6B8) [NBP3-19800]

Western Blot: USP7 Antibody (S02-6B8) [NBP3-19800]

Western Blot: USP7 Antibody (S02-6B8) [NBP3-19800] - Western blot detection of USP7 in C6 cell lysates using NBP3-19800 (1:1000 diluted). Predicted band size: 128kDa. Observed band size: 128kDa.
Immunohistochemistry-Paraffin: USP7 Antibody (S02-6B8) [NBP3-19800]

Immunohistochemistry-Paraffin: USP7 Antibody (S02-6B8) [NBP3-19800]

Immunohistochemistry-Paraffin: USP7 Antibody (S02-6B8) [NBP3-19800] - Immunohistochemistry of USP7 in paraffin-embedded Human lung cancer tissue using NBP3-19800 at dilution 1/20

Applications for USP7 Antibody (S02-6B8)

Application
Recommended Usage

Immunohistochemistry

1/20

Western Blot

1/1000

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.05% BSA

Preservative

0.01% Sodium Azide

Concentration

0.3 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: USP7

HAUSP (also known as deubiquitinating enzyme 7, herpes virus associated ubiquitin specific protease, TEF1, ubiquitin carboxyl terminal hydrolase 7, ubiquitin specific protease 7, ubiquitin thiolesterase 7, and USP7) is a novel p53 interacting protein. HAUSP was identified by mass spectrometry of affinity-purified p53 associated factors by Li et al. HAUSP strongly stabilizes p53 even in the presence of excess MDM2, and also induces p53-dependent cell growth repression and apoptosis. HAUSP has an intrinsic enzymatic activity that specifically de-ubiquitinates p53 both in vivo and in vitro. Expression of a catalytically inactive point mutation of HAUSP in cells increased the levels of p53 ubiquitination and also destabilized p53. Li et al concluded that their findings revealed an important mechanism by which p53 can be stabilized by direct de-ubiquitination and also implied that HAUSP may function as a tumor suppressor in vivo through the stabilization of p53.

Long Name

Ubiquitin Specific Protease 7

Alternate Names

HAUSP, TEF1

Gene Symbol

USP7

Additional USP7 Products

Product Documents for USP7 Antibody (S02-6B8)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for USP7 Antibody (S02-6B8)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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